Fluorescence-based optical fiber sensor for liquid sample analysis in silica glass well

Abstract

Liquid samples are often of interest for various analytical purposes, requiring rapid, precise, portable, and easy-to-use equipment. Then, we proposed a portable system for fluorescence spectroscopy was developed, integrating an optical fiber sensor into a single-well plate. A proof-of-concept of the system was demonstrated using two different fluorescence samples: chlorophyll and cyanobacteria culture. The manufacturing method employed was ultrafast laser-assisted etching (ULAE), and the optical fiber was custom-mounted for tip-endcap integration. The fluorescence analysis demonstrated an enhancement in the signal of the liquid sample through the integration of the fiber capture system in the detector.