Mostrar el registro sencillo

Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

dc.contributor.authorCabrera Alarcon, José Luis
dc.contributor.authorCruz, Raquel
dc.contributor.authorRosa Moreno, Marina
dc.contributor.authorLatorre Pellicer, Ana
dc.contributor.authorDe Almeida, Silvia Diz
dc.contributor.authorCarracedo, Ángel
dc.contributor.authorLapunzina, Pablo
dc.contributor.authorRojas Martinez, Augusto
dc.contributor.authorRiancho Moral, José Antonio 
dc.contributor.authorFlores, Carlos
dc.contributor.authorZazo, Sandra
dc.contributor.authorZarate, Ruth
dc.contributor.authorZapatero Gaviria, Antonio
dc.contributor.authorYáñez, Zuleima
dc.contributor.authorCosta, Tatiana X.
dc.contributor.authorVirseda-Berdices, Ana
dc.contributor.authorVilloslada-Blanco, Pablo
dc.contributor.authorVillaverde, Cristina
dc.contributor.authorVillar-Garcia, Judit
dc.contributor.authorGarcía Ibarbia, María del Carmen 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2025-06-04T14:46:27Z
dc.date.available2025-06-04T14:46:27Z
dc.date.issued2025
dc.identifier.issn2399-3642
dc.identifier.otherPID2021-1279880B
dc.identifier.otherTED2021-131611B-I00
dc.identifier.otherPID2022-141527OB-I00es_ES
dc.identifier.urihttps://hdl.handle.net/10902/36497
dc.description.abstractThe frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.es_ES
dc.description.sponsorshipAcknowledgments: The authors thank M. M. Muñoz-Hernandez, R. Martínez de Mena and E.R. Martínez Jiménez, for technical assistance. Scheme figures were made with BioRender. We particularly acknowledge all the patients, Banco Nacional de ADN, Biobanco del Sistema de Salud de Aragón, Biobanc Fundació Institut d'Investigació Sanitària Illes Balears, Biobanco del Complexo Hospitalario Universitario de Santiago, Biobanco Vasco, for their collaboration and providing materials. JAE laboratory is supported by: RTI2018-099357-B-I00 and PID2021-1279880B-and TED2021-131611B-I00 funded by MCIN/AEI/ 10.13039/501100011033 and the, and CIBERFES (CB16/10/00282), Human Frontier Science Program (grant RGP0016/2018), and Leducq Transatlantic Networks (17CVD04). MR-M is supported by a FPI/PRE2021- 097721 fellowship. JAE and FSC are supported by TED2021-131611B-I00 funded by MCIN/AEI/10.13039/501100011033 and the European Union “NextGenerationEU”/Plan de Recuperación Transformación y Resiliencia -PRTR. FSC received funding [grant no. PID2022-141527OB-I00] by the MCIN/AEI/10.13039/501100011033/ and by FEDER Una manera de hacer Europa. This work was supported by Fundación Amancio Ortega Gaona, Banco de Santander S.A. and Instituto de Salud Carlos III (COV20/00622) and the European Regional Development Fund. Genotyping service was carried out at CEGEN-PRB3-ISCIII, supported by grant PT17/0019, of the PE I+D+i 2013-2016, funded by ISCIII and ERDF. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation) and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/ 501100011033).es_ES
dc.format.extent12 p.es_ES
dc.language.isoenges_ES
dc.publisherNaturees_ES
dc.rights© The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceCommunications Biology, 2025, 8(1), 33es_ES
dc.subject.otherCOVID-19es_ES
dc.subject.otherDNA, mitochondriales_ES
dc.subject.otherEuropees_ES
dc.subject.otherGenome-wide association studyes_ES
dc.subject.otherHaplotypeses_ES
dc.subject.otherHumanses_ES
dc.subject.otherMalees_ES
dc.subject.otherMitochondriaes_ES
dc.subject.otherSARS-CoV-2es_ES
dc.subject.otherSeverity of Illness Indexes_ES
dc.titleShaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1038/s42003-024-07314-yes_ES
dc.rights.accessRightsopenAccesses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-141527OB-I00/ES/GEMELOS DIGITALES PARA MEDICINA CARDIOVASCULAR DE PRECISION/
dc.identifier.DOI10.1038/s42003-024-07314-y
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail
Nombre:
ShapingCurrentEuropeanMitochon ...
Tamaño:
1.146Mb
Formato:
PDF
Descripción:
ShapingCurrentEuropeanMitochondrial

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

© The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International LicenseExcepto si se señala otra cosa, la licencia del ítem se describe como © The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License