Analysis of photodynamic therapy applied to skin disorders by a topical photosensitizer

Abstract

Optical treatment of pathological tissues comprises techniques like Low Intensity Laser Treatment (LILT) or Photodynamic Therapy (PDT). PDT consists on the inoculation of a photosensitizer in the tissue, which tends to be accumulated in cancerous cells, and on the posterior optical radiation of the area. The photosensitizer, that can be topical or systemic, is excited and cell necrosis is provoked. The collateral harmful effects of other destructive techniques, like radiotherapy or chemotherapy, are avoided with PDT. PDT can also be used as a complementary technique of conventional excisional surgical operations. The application of PDT to skin disorders is straightforward due to the fact that it is an external and accessible tissue. In this work, we analyze the application of PDT to several skin pathologies and the results obtained, by means of mainly the usage of Metvix® as a topical photosensitizer and with an optical source in the range of 635 nm. The analysis includes a predictive model of the PDT process, based on an optical propagation equation and a photosensitizer degradation approach that provides an estimation of tissue destruction.