dc.contributor.author | Serradilla-Martín, Mario | |
dc.contributor.author | Villodre, Celia | |
dc.contributor.author | Falgueras-Verdaguer, Laia | |
dc.contributor.author | Zambudio-Carroll, Natalia | |
dc.contributor.author | Castell-Gómez, José T. | |
dc.contributor.author | Blas-Laina, Juan L. | |
dc.contributor.author | Borrego-Estella, Vicente | |
dc.contributor.author | Domingo-del-Pozo, Carlos | |
dc.contributor.author | García-Plaza, Gabriel | |
dc.contributor.author | González-Rodríguez, Francisco J. | |
dc.contributor.author | Montalvá-Orón, Eva | |
dc.contributor.author | Moya-Herraiz, Ángel | |
dc.contributor.author | Paterna-López, Sandra | |
dc.contributor.author | Suárez-Muñoz, Miguel A. | |
dc.contributor.author | Alkorta-Zuloaga, Maialen | |
dc.contributor.author | Blanco-Fernández, Gerardo | |
dc.contributor.author | Dabán-Collado, Enrique | |
dc.contributor.author | Gómez-Bravo, Miguel A. | |
dc.contributor.author | Rodríguez Sanjuán, Juan Carlos | |
dc.contributor.other | Universidad de Cantabria | es_ES |
dc.date.accessioned | 2024-08-01T08:24:44Z | |
dc.date.available | 2024-08-01T08:24:44Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://hdl.handle.net/10902/33356 | |
dc.description.abstract | (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted. | es_ES |
dc.format.extent | 16 p. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution 4.0 International | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Cancers, 2024, 16, 1676 | es_ES |
dc.subject.other | Colorectal cancer | es_ES |
dc.subject.other | Liver metastases | es_ES |
dc.subject.other | Liver-first approach | es_ES |
dc.subject.other | Disease-free survival | es_ES |
dc.title | Feasibility and short-term outcomes in liver-first approach: a Spanish snapshot study (the RENACI Project) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | openAccess | es_ES |
dc.identifier.DOI | 10.3390/cancers16091676 | |
dc.type.version | publishedVersion | es_ES |