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dc.contributor.authorSerradilla-Martín, Mario
dc.contributor.authorVillodre, Celia
dc.contributor.authorFalgueras-Verdaguer, Laia
dc.contributor.authorZambudio-Carroll, Natalia
dc.contributor.authorCastell-Gómez, José T.
dc.contributor.authorBlas-Laina, Juan L.
dc.contributor.authorBorrego-Estella, Vicente
dc.contributor.authorDomingo-del-Pozo, Carlos
dc.contributor.authorGarcía-Plaza, Gabriel
dc.contributor.authorGonzález-Rodríguez, Francisco J.
dc.contributor.authorMontalvá-Orón, Eva
dc.contributor.authorMoya-Herraiz, Ángel
dc.contributor.authorPaterna-López, Sandra
dc.contributor.authorSuárez-Muñoz, Miguel A.
dc.contributor.authorAlkorta-Zuloaga, Maialen
dc.contributor.authorBlanco-Fernández, Gerardo
dc.contributor.authorDabán-Collado, Enrique
dc.contributor.authorGómez-Bravo, Miguel A.
dc.contributor.authorRodríguez Sanjuán, Juan Carlos 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2024-08-01T08:24:44Z
dc.date.available2024-08-01T08:24:44Z
dc.date.issued2024
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10902/33356
dc.description.abstract(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.es_ES
dc.format.extent16 p.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceCancers, 2024, 16, 1676es_ES
dc.subject.otherColorectal canceres_ES
dc.subject.otherLiver metastaseses_ES
dc.subject.otherLiver-first approaches_ES
dc.subject.otherDisease-free survivales_ES
dc.titleFeasibility and short-term outcomes in liver-first approach: a Spanish snapshot study (the RENACI Project)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.3390/cancers16091676
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International