Mostrar el registro sencillo

dc.contributor.authorMartínez Meñaca, Amaya
dc.contributor.authorCruz-Utrilla, Alejandro
dc.contributor.authorMora Cuesta, Víctor Manuel
dc.contributor.authorLuna-López, Raquel
dc.contributor.authorSegura-de la Cal, Teresa
dc.contributor.authorFlox-Camacho, Ángela
dc.contributor.authorAlonso Lecue, Pilar
dc.contributor.authorEscribano-Subias, Pilar
dc.contributor.authorCifrián Martínez, José Manuel 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2024-05-15T13:39:55Z
dc.date.available2024-05-15T13:39:55Z
dc.date.issued2024
dc.identifier.issn2045-8940
dc.identifier.issn2045-8932
dc.identifier.urihttps://hdl.handle.net/10902/32844
dc.description.abstractA simplified 4-strata risk stratification approach based on three variables is widespread in pulmonary arterial hypertension (PAH) at follow-up. This study aimed to assess the impact of replacing the 6-min walk test (6MWT) with the peak 02 uptake evaluated by the cardiopulmonary exercise test (CPET) on risk stratification by this scale. We included 180 prevalent patients with PAH from two reference hospitals in Spain, followed up between 2006 and 2022. Patients were included if all the variables of interest were available within a 3-month period on the Spanish Registry of Pulmonary Arterial Hypertension (REHAP): functional class (FC); NT-proBNP; 6MWT; and CPET. The original 4-strata model (NT-proBNP, 6MWT, FC) identified most patients at low or intermediate-low risk (36.7% and 51.1%, respectively). Notably, the modified scale (NT-proBNP, CPET, FC) improved the identification of patients at intermediate-high risk up to 18.9%, and at high risk up to 1.1% in comparison with the previous 12.2% and 0.0% in the original scale. This new model increased the number of patients correctly classified into higher-risk strata (positive NRI of 0.06), as well as classified more patients without events in lower-risk strata (negative NRI of 0.04). The proposed score showed a slightly superior prognostic capacity compared with the original model (Harrel's C-index 0.717 vs. 0.709). Using O2 uptake instead of distance walked in the 6MWT improves the identification of high-risk patients using the 4-strata scale. This change could have relevant prognostic implications and lead to changes in the specific treatment of PAH.es_ES
dc.description.sponsorshipFunding information: None ACKNOWLEDGMENTS: Alejandro Cruz‐Utrilla holds a research‐training contract “Rio Hortega” (CM20/00164) from the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos III). This research did not receive any fund from any public, private, or nonprofit entity.es_ES
dc.format.extent11 p.es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institutees_ES
dc.rights© 2024 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.es_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourcePulmonary Circulation, 2024, 14, e12342es_ES
dc.subject.otherCardiopulmonary exercise testes_ES
dc.subject.otherPulmonary arterial hypertensiones_ES
dc.subject.otherRisk assessmentes_ES
dc.subject.other6 min walking testes_ES
dc.titleSimplified risk stratification based on cardiopulmonary exercise test: A Spanish two-center experiencees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1002/pul2.12342es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1002/pul2.12342
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

© 2024 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Excepto si se señala otra cosa, la licencia del ítem se describe como © 2024 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.