Mostrar el registro sencillo

A mathematical justification for metronomic chemotherapy in oncology

dc.contributor.authorFernández Fernández, Luis Alberto 
dc.contributor.authorPola Méndez, Cecilia 
dc.contributor.authorSáinz-Pardo Díaz, Judith 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2024-05-06T18:45:43Z
dc.date.available2024-05-06T18:45:43Z
dc.date.issued2022
dc.identifier.issn1760-6101
dc.identifier.issn0973-5348
dc.identifier.otherMTM2017-83185-Pes_ES
dc.identifier.otherPID2020-114837GB-I00es_ES
dc.identifier.urihttps://hdl.handle.net/10902/32759
dc.description.abstractWe mathematically justify metronomic chemotherapy as the best strategy to apply many cytotoxic drugs in oncology for both curative and palliative approaches, assuming the classical pharmacokinetic model together with the Emax pharmacodynamic and the Norton-Simon hypothesis. From the mathematical point of view, we will consider two mixed-integer nonlinear optimization problems, where the unknowns are the number of the doses and the quantity of each one, adjusting the administration times a posteriori.es_ES
dc.description.sponsorshipWe thank the reviewers for their comments, which have contributed to improving the work. The first and second authors were supported by MCIN/ AEI/10.13039/501100011033/ under research projects MTM2017-83185-P and PID2020-114837GB-I00.es_ES
dc.format.extent18 p.es_ES
dc.language.isoenges_ES
dc.publisherEDP Scienceses_ES
dc.rights© The authors. Published by EDP Sciences, 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.es_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceMathematical Modelling of Natural Phenomena, 2022, 17, 2022010es_ES
dc.subject.otherMetronomic chemotherapyes_ES
dc.subject.otherMixed-integer nonlinear optimizationes_ES
dc.subject.otherNorton-Simon hypothesises_ES
dc.subject.otherEmax modeles_ES
dc.titleA mathematical justification for metronomic chemotherapy in oncologyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1051/mmnp/2022010es_ES
dc.rights.accessRightsopenAccesses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-83185-P/ES/CONTROL OPTIMO DE ECUACIONES EN DERIVADAS PARCIALES NO LINEALES Y APLICACIONES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114837GB-I00/ES/CONTROL OPTIMO DE ECUACIONES EN DERIVADAS PARCIALES NO LINEALES. ESTUDIO TEORICO, ANALISIS NUMERICO Y APLICACIONES/
dc.identifier.DOI10.1051/mmnp/2022010
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail
Nombre:
MathematicalJustificationMetro ...
Tamaño:
654.5Kb
Formato:
PDF
Descripción:
MathematicalJustificationMetronomic

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

© The authors. Published by EDP Sciences, 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Excepto si se señala otra cosa, la licencia del ítem se describe como © The authors. Published by EDP Sciences, 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.