Mostrar el registro sencillo

dc.contributor.authorSonderby, Ida E.
dc.contributor.authorGústafsson, Ómar
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorHibar, Derrek P.
dc.contributor.authorMartin-Brevet, Sandra
dc.contributor.authorAbdellaoui, Abdel
dc.contributor.authorAmes, David
dc.contributor.authorAmunts, Katrin
dc.contributor.authorAndersson, Michael
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorBernard, Manon
dc.contributor.authorBlackburn, Nicholas
dc.contributor.authorBlangero, John
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBralten, Janita
dc.contributor.authorBrattbak, Hans-Richard
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBrouwer, Rachel M.
dc.contributor.authorCrespo Facorro, Benedicto 
dc.contributor.authorRoiz Santiañez, Roberto
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2024-02-09T13:24:11Z
dc.date.available2024-02-09T13:24:11Z
dc.date.issued2020
dc.identifier.issn1359-4184
dc.identifier.issn1476-5578
dc.identifier.otherSAF2013-46292-R
dc.identifier.otherSAF2015-71526-REDT
dc.identifier.urihttps://hdl.handle.net/10902/31623
dc.description.abstractCarriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (??=??0.71 to ?1.37; P?<?0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (??=??0.95, P?=?0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P?=?0.0032, 8.9?×?10?6, 1.7?×?10?9, 3.5?×?10?12 and 1.0?×?10?4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.es_ES
dc.description.sponsorship1000BRAINS is a populationbased cohort based on the Heinz-Nixdorf Recall Study and is supported in part by the German National Cohort. We thank the Heinz Nixdorf Foundation (Germany) for their generous support in terms of the Heinz Nixdorf Study. The HNR study is also supported by the German Ministry of Education and Science (FKZ 01EG940), and the German Research Council (DFG, ER 155/6-1). The authors are supported by the Initiative and Networking Fund of the Helmholtz Association (Svenja Caspers) and the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement 7202070 (Human Brain Project SGA1; Katrin Amunts, Sven Cichon). This work was further supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network 592 I. E. Sønderby et al. IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders) under the auspices of the e:Med Program (grant 01ZX1314A to M.M.N. and S.C.), and by the Swiss National Science Foundation (SNSF, grant 156791 to S.C.). 16p.11.2 European Consortium: B.D. is supported by the Swiss National Science Foundation (NCCR Synapsy, project grant Nr 32003B_159780) and Foundation Synapsis. LREN is very grateful to the Roger De Spoelberch and Partridge Foundations for their generous financial support. This work was supported by grants from the Simons Foundation (SFARI274424) and the Swiss National Science Foundation (31003A_160203) to A.R. and S.J. Betula: The relevant Betula data collection and analyses were supported by a grant from the Knut & Alice Wallenberg (KAW) to L. Nyberg. Brainscale: the Brainscale study was supported by the Netherlands Organization for Scientific Research MagW 480-04-004 (Dorret Boomsma), 51.02.060 (Hilleke Hulshoff Pol), 668.772 (Dorret Boomsma & Hilleke Hulshoff Pol); NWO/SPI 56-464-14192 (Dorret Boomsma), the European Research Council (ERC-230374) (Dorret Boomsma), High Potential Grant Utrecht University (Hilleke Hulshoff Pol), NWO Brain and Cognition 433-09-220 (Hilleke Hulshoff Pol). Brain Imaging Genetics (BIG): This work makes use of the BIG database, first established in Nijmegen, The Netherlands, in 2007. This resource is now part of Cognomics (www.cognomics.nl), a joint initiative by researchers of the Donders Centre for Cognitive Neuroimaging, the Human Genetics and Cognitive Neuroscience departments of the Radboud university medical centre and the Max Planck Institute for Psycholinguistics in Nijmegen. The Cognomics Initiative has received supported from the participating departments and centres and from external grants, i.e., the Biobanking and Biomolecular Resources Research Infrastructure (the Netherlands) (BBMRI-NL), the Hersenstichting Nederland, and the Netherlands Organisation for Scientific Research (NWO). The research leading to these results also receives funding from the NWO Gravitation grant ‘Language in Interaction’, the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreements n° 602450 (IMAGEMEND), n°278948 (TACTICS), and n°602805 (Aggressotype) as well as from the European Community’s Horizon 2020 programme under grant agreement n° 643051 (MiND) and from ERC-2010-AdG 268800-NEUROSCHEMA. In addition, the work was supported by a grant for the ENIGMA Consortium (grant number U54 EB020403) from the BD2K Initiative of a cross-NIH partnership. COBRE: This work was supported by a NIH COBRE Phase I grant (1P20RR021938, Lauriello, PI and 2P20GM103472, Calhoun, PI) awarded to the Mind Research Network. We wish to express our gratitude to numerous investigators who were either external consultants to the Cores and projects, mentors on the projects, members of the external advisory committee and members of the internal advisory committee. Decode: The research leading to these results has received financial contribution from the European Union’s Seventh Framework Programme (EU-FP7/2007–2013), EU-FP7 funded grant no. 602450 (IMAGEMEND) as well as support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no.115300 (EUAIMS). DemGene: Norwegian Health Association and Research Council of Norway. Dublin: Work was supported by Science Foundation Ireland (SFI grant 12/IP/1359 to Gary Donohoe and SFI08/IN.1/B1916-Corvin to Aidan C Corvin) and the European Research Council (ERC-StG-2015-677467). EPIGEN-UK (SMS, CL): The work was partly undertaken at UCLH/UCL, which received a proportion of funding from the UK Department of Health’s NIHR Biomedical Research Centres funding scheme. We are grateful to the Wolfson Trust and the Epilepsy Society for supporting the Epilepsy Society MRI scanner, and the Epilepsy Society for supporting CL. Haavik: The work at the K.G.Jebsen center for neuropsychiatric disorders at the University of Bergen, Norway, was supported by Stiftelsen K.G. Jebsen, European Community’s Seventh Framework Program under grant agreement no 602805 and the H2020 Research and Innovation Program under grant agreement numbers 643051 and 667302. HUNT: The HUNT Study is a collaboration between HUNT Research Centre (Faculty of Medicine, Norwegian University of Science and Technology), Nord-Trøndelag County Council, Central Norway Health Authority, and the Norwegian Institute of Public Health. HUNT-MRI was funded by the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and Technology, and the Norwegian National Advisory Unit for functional MRI. IMAGEN: The work received support from the European Union-funded FP6Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT- 2007-037286), the Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313), ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) (MR/N027558/1), the FP7 projects IMAGEMEND (602450; IMAging GEnetics for MENtal Disorders) and MATRICS (603016), the Innovative Medicine Initiative Project EUAIMS (115300), the Medical Research Council Grant ‘c-VEDA’ (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the Swedish Research Council FORMAS, the Medical Research Council, the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, the Bundesministeriumfür Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A; Forschungsnetz AERIAL), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-1, SM 80/7-2, SFB 940/1). Further support was provided by grants from: ANR (project AF12-NEUR0008-01—WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche Médicale, the Mission Interministérielle de Lutte-contreles-Drogues-et-les-Conduites-Addictives (MILDECA), the AssistancePublique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012; the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), USA (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. MCIC: This work was supported primarily by the Department of Energy DE-FG02-99ER62764 through its support of the Mind Research Network and the consortium as well as by the National Association for Research in Schizophrenia and Affective Disorders (NARSAD) Young Investigator Award (to SE) as well as through the Blowitz-Ridgeway and Essel Foundations, and through NWO ZonMw TOP 91211021, the DFG research fellowship (to SE), the Mind Research Network, National Institutes of Health through NCRR 5 month-RR001066 (MGH General Clinical Research Center), NIMH K08 MH068540, the Biomedical Informatics Research Network with NCRR Supplements to P41 RR14075 (MGH), M01 RR 01066 (MGH), NIBIB R01EB006841 (MRN), R01EB005846 (MRN), 2R01 EB000840 (MRN), 1RC1MH089257 (MRN), as well as grant U24 RR021992. NCNG: this sample collection was supported by grants from the Bergen Research Foundation and the University of Bergen, the Dr Einar Martens Fund, the K.G. Jebsen Foundation, the Research Council of Norway, to SLH, VMS and TE. The Bergen group was supported by grants from the Western Norway Regional Health Authority (Grant 911593 to AL, Grant 911397 and 911687 to AJL). NESDA: Funding for NESDA was obtained from the Netherlands Organization for Scientific Research (Geestkracht program grant 10-000-1002); the Center for Medical Systems Biology (CSMB, NWO Genomics), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL), VU University’s Institutes for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam, University Medical Center Groningen, Leiden University Medical Center, National Institutes of Health (NIH, R01D0042157-01A, MH081802, 16p11.2 distal copy number variant brain structure 593 Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health.Computing was supported by BiG Grid, the Dutch e-Science Grid, which is financially supported by NWO. NTR: The NTR study was supported by the Netherlands Organization for Scientific Research (NWO), MW904-61-193 (Eco de Geus & Dorret Boomsma), MaGW-nr: 400-07- 080 (Dennis van ‘t Ent), MagW 480-04-004 (Dorret Boomsma), NWO/SPI 56-464-14192 (Dorret Boomsma), the European Research Council, ERC-230374 (Dorret Boomsma), and Amsterdam Neuroscience. OATS: OATS (Older Australian Twins Study) was facilitated by access to Twins Research Australia, which is funded by a National Health and Medical Research Council (NHMRC) Enabling Grant 310667. OATS is also supported via a NHMRC/Australian Research Council Strategic Award (401162) and a NHMRC Project Grant (1045325). DNA extraction was performed by Genetic Repositories Australia, which was funded by a NHMRC Enabling Grant (401184). OATS genotyping was partly funded by a Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund Grant. PAFIP: PAFIP data were collected at the Hospital Universitario Marqués de Valdecilla, University of Cantabria, Santander, Spain, under the following grant support: Carlos III Health Institute PIE14/00031 and SAF2013-46292-R and SAF2015-71526-REDT. We wish to acknowledge IDIVAL Neuroimaging Unit for imaging acquirement and analysis.We want to particularly acknowledge the patients and the BioBankValdecilla (PT13/0010/0024) integrated in the Spanish National Biobanks Network for its collaboration. QTIM: The QTIM study was supported by grants from the US National Institute of Child Health and Human Development (R01 HD050735) and the Australian National Health and Medical Research Council (NHMRC) (486682, 1009064). Genotyping was supported by NHMRC (389875). Lachlan Strike is supported by an Australian Postgraduate Award (APA). AFM is supported by NHMRC CDF 1083656. We thank the twins and siblings for their participation, the many research assistants, as well as the radiographers, for their contribution to data collection and processing of the samples. SHIP: SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, 01ZZ0403 and 01ZZ0701), the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania, and the network ‘Greifswald Approach to Individualized Medicine (GANI_MED)’ funded by the Federal Ministry of Education and Research (grant 03IS2061A). Genome-wide data have been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg- West Pomerania. Whole-body MR imaging was supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg West Pomerania. The University of Greifswald is a member of the Caché Campus program of the InterSystems GmbH. StrokeMRI: StrokeMRI has been supported by the Research Council of Norway (249795), the South-Eastern Norway Regional Health Authority (2014097, 2015044, 2015073) and the Norwegian ExtraFoundation for Health and Rehabilitation. TOP: TOP is supported by the Research Council of Norway (223273, 213837, 249711), the South East Norway Health Authority (2017-112), the Kristian Gerhard Jebsen Stiftelsen (SKGJ‐MED‐008) and the European Community’s Seventh Framework Programme (FP7/2007–2013), grant agreement no. 602450 (IMAGEMEND). We acknowledge the technical support and service from the Genomics Core Facility at the Department of Clinical Science, the University of Bergen for the 16p11.2 European Consortium; for the ENIGMA-CNV working group Ida Elken Sønderby (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Ómar Gústafsson (deCODE Genetics/Amgen, Reykjavik, Iceland), Nhat Trung Doan (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Derrek Paul Hibar (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA), (Janssen Research and Development, La Jolla, CA USA, Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, U. S.A), Sandra Martin-Brevet (Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland), Abdel Abdellaoui (Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT Amsterdam, The Netherlands), (Department of Psychiatry, Academic Medical Center, Amsterdam, the Netherlands), David Ames (National Ageing Research Institute, Melbourne, Australia), (Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia), Katrin Amunts (Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425 Juelich, Germany), (C. and O. Vogt Institute for Brain Research, Medical Faculty, University of Dusseldorf, Merowingerplatz 1A, 40225 Dusseldorf, Germany), (JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425 Juelich, Germany), Michael Andersson (Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187 Umeå, Sweden), Nicola J. Armstrong (Mathematics and Statistics, Murdoch University, Perth, Australia), Manon Bernard (The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada), Nicholas Blackburn (South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520 Brownsville, TX, USA), John Blangero (South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520 Brownsville, TX, USA), Dorret I Boomsma (Netherlands Twin Register, Vrije Universiteit, van der Boechorststraat 1, 1081BT Amsterdam, Netherlands), Janita Bralten (Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands), Hans-Richard Brattbak (Department of Clinical Science, University of Bergen, Bergen, Norway), (Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway), Henry Brodaty (Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, UNSW, Sydney, Australia), Rachel M. Brouwer (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), Robin Bülow (Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany), Vince Calhoun (The Mind Research Network, The University of New Mexico, Albuquerque, NM), Svenja Caspers (Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425 Juelich, Germany), (C. and O. Vogt Institute for Brain Research, Medical Faculty, University of Dusseldorf, Merowingerplatz 1A, 40225 Dusseldorf, Germany), (JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425 Juelich, Germany), Gianpiero Cavalleri (The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland), Chi-Hua Chen (Department of Radiology, University of California San Diego, La Jolla, USA), (Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA), Sven Cichon (Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Leo-Brandt-Strasse 5, 52425 Jülich, Germany), (Human Genomics Research Group, 594 I. E. Sønderby et al. Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland), (Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland), Simone Ciufolini (Psychosis Studies, Insitute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespingy Park, SE5 8AF London, United Kingdom), Aiden Corvin (Neuropsychiatric Genetics Research Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.), Benedicto Crespo-Facorro (Department of Medicine and Psychiatry, University Hospital Marque?s de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008 Santander, Spain), (CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain), Joanne E. Curran (South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520 Brownsville, TX, USA), Anders M Dale (Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA), Shareefa Dalvie (Department of Psychiatry and Mental Health, Anzio Road, 7925 Cape Town, South Africa), Paola Dazzan (Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, SE5 8AF London, United Kingdom), (National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, United Kingdom), Eco JC de Geus (Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, van der Boechorststraat 1, 1081 BT Amsterdam, Netherlands), (Amsterdam Neuroscience, VU University medical center, van der Boechorststraat 1, 1081 BT Amsterdam, NH, Netherlands), Greig I. de Zubicaray (Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia), Sonja M.C. de Zwarte (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), Norman Delanty (The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland), (Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, 4860 Y Street, Suite 3700, Sacramento, California 95817, USA.), Anouk den Braber (Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, van der Boechorststraat 1, 1081 BT Amsterdam, Netherlands), (Alzheimer Center and Department of Neurology, VU University Medical Center, De Boelelaan 1105, 1081HV Amsterdam Amsterdam, Amsterdam), Sylvane Desrivières (Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom), Gary Donohoe (Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, H91 TK33, Galway, Ireland), (Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland), Bogdan Draganski (LREN - Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland), (Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany), Stefan Ehrlich (Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307 Dresden, Germany), (Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA), (Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA), Thomas Espeseth (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), Simon E. Fisher (Language and Genetics Department, Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD Nijmegen, Netherlands), (Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands), Barbara Franke (Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands), (Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands), (Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands), Vincent Frouin (NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France), Masaki Fukunaga (Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan), Thomas Gareau (NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France), David C. Glahn (Yale University School of Medicine, 40 Temple Street, Suite 6E, 6511 New Haven, Vaud, USA), (Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, 300 George Street, 6106 Hartford, CT, USA), Hans Grabe (Department of Psychiatry und Psychotherapy, University Medicine Greifswald, Germany), Nynke A. Groenewold (Department of Psychiatry and Mental Health, Anzio Road, 7925 Cape Town, South Africa), Jan Haavik (K. G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway), Asta Håberg (Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology), Ryota Hashimoto (Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan), Jayne Y. Hehir-Kwa (Princess Máxima Center for Pediatric Oncology, Lundlaan 6, 3584 EA Utrecht, The Netherlands), Andreas Heinz (Dept. of Psychiatry and Psychotherapie, Charite, Humboldt University, Chariteplatz 1, 10017 Berlin, Germany), Manon H.J. Hillegers (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), (Child and adolescent Psychiatry / Psychology, Erasmus medical center-Sophia's Childerens hospitaal, Rotterdam, Wytemaweg 8, 3000 CB Rotterdam, The Netherlands), Per Hoffmann (Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Leo-Brandt-Strasse 5, 52425 Jülich, Germany), (Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland), (Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany), Laurena Holleran (The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland), Jouke-Jan Hottenga (Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT Amsterdam, The Netherlands), Hilleke E. Hulshoff (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), Masashi Ikeda (Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan), Neda Jahanshad (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA), Terry Jernigan (Center for Human Development, University of California San Diego, CA, USA), Christiane Jockwitz (Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425 Juelich, Germany), (JARA-BRAIN, Juelich-Aachen Research Alliance, WilhelmJohnen-Str., 52425 Juelich, Germany), (Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Medical Faculty, Pauwelsstraße 30, 52074 Aachen, Germany), Stefan Johansson (Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway), (K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway), Gudrun A. Jonsdottir (deCODE Genetics/Amgen, Reykjavik, Iceland), Erik G. Jönsson (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 16p11.2 distal copy number variant brain structure 595 Oslo, Norway), (Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital Solna, R5:00, SE-17176 Stockholm, Sweden), Rene Kahn (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), Tobias Kaufmann (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Sinead Kelly (The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland), Masataka Kikuchi (Department of Genome Informatics, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan), Emma EM. Knowles (Department of Psychiatry, Yale University, 40 Temple Street, 6515 New Haven, CT, USA), Knut K. Kolskår (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), (Sunnaas Rehabilitation Hospital HT, Nesodden, Norway), John B. Kwok (Brain and Mind Centre, University of Sydney, Australia), Stephanie Le Hellard (NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway), (Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, and Chalfont Centre for Epilepsy, UK), Costin Leu (Department of Clinical and Experimental Epilepsy, NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, 33 Queen Square, WC1N 3BG London, United Kingdom), Jingyu Liu (The Mind Research Network, 1101 Yale Blvd., 87106 Albuquerque, CT, USA), (Dept. of Electrical and Computer Engineering, University of New Mexico, 87131 Albuquerque, New Mexico, USA), Astri J. Lundervold (Yale University School of Medicine, 40 Temple Street, Suite 6E, 6511 New Haven, Vaud, USA), (Department of Biological and Medical Psychology, Jonas Lies vei 91, N-5009 Bergen, Norway), Arvid Lundervold (Department of Biomedicine, University of Bergen, 5009, Bergen, Norway), Nicholas G. Martin (QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia), Karen Mather (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia), Samuel R. Mathias (Department of Psychiatry, Yale University, 40 Temple Street, 6515 New Haven, CT, USA), Mark McCormack (Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, D02 YN77 Dublin, Ireland), (Centre for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands), Katie L. McMahon (Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia), Allan McRae (Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia), Yuri Milaneschi (Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands, Oldenaller 1, 1081 HJ Amsterdam, The Netherlands), Clara Moreau (CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada), Derek Morris (Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, H91 TK33, Galway, Ireland), (Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland), David Mothersill (The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland), Thomas W. Mühleisen (Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Leo-Brandt-Strasse 5, 52425 Jülich, Germany), (Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland), Robin Murray (Departments of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom), Jan E. Nordvik (Sunnaas Rehabilitation Hospital HT, Nesodden, Norway), Lars Nyberg (Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187 Umeå, Sweden), Loes M. Olde Loohuis (Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA), Roel Ophoff (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), (Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA), Tomas Paus (Rotman Research Institute, University of Toronto, Toronto, M6A 2E1, Canada), (Department of Psychiatry, University of Toronto, Toronto, M5S 1A1, Canada), (Center for Developing Brain, Child Mind Institute, New York, NY, 10022, USA), (Department of Psychology, University of Toronto, Toronto, M5S 1A1, Canada), Zdenka Pausova (The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada), Brenda Penninx (Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical), Juan M. Peralta (South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520 Brownsville, TX, USA), Bruce Pike (Departments of Radiology & Clinical Neuroscience, University of Calgary, Calgary, T2N 1N4, Canada), Carlos Prieto (Bioinformatics Service, Nucleus, University of Salamanca (USAL), 37007 Salamanca, Spain), Sara Pudas (Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187 Umeå, Sweden), (Department of Integrative Medical Biology, Linnéus väg 9, 901 87 Umeå, Sweden), Erin Quinlan (Centre for Population Neuroscience and Stratified Medicine, Social, Genetic and Development Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF London, UK), Daniel S. Quintana (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), Céline S. Reinbold (Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland), (Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031 Basel, Switzerland), Tiago Reis Marques (Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, SE5 8AF London, United Kingdom), (Psychiatry Imaging Group, MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN London, UK), Alexandre Reymond (Center for Integrative Genomics, University of Lausanne, Genopode building, CH-1015 Lausanne, Switzerland), Genevieve Richard (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), (Sunnaas Rehabilitation Hospital HT, Nesodden, Norway), Borja Rodriguez-Herreros (Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland), (CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada), Roberto Roiz-Santiañez (Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008 Santander, Spain), (CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain), James Rucker (National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS 596 I. E. Sønderby et al. Foundation Trust and King's College London, United Kingdom), (Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom), Perminder Sachdev (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia), Anne-Marthe Sanders (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), (Sunnaas Rehabilitation Hospital HT, Nesodden, Norway), Sigrid B. Sando (Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology), (Department of Neurology, University Hospital of Trondheim, Edvard Griegs gate 8, N-7006 Trondheim, Norway), Lianne Schmaal (Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, 3502 Parkville, New Mexico, Australia), (Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Victoria, Australia), (Department of Psychiatry, VU University Medical Center, 1007 MB Amsterdam, The Netherlands), Peter R. Schofield (Neuroscience Research Australia, Randwick, Australia), (School of Medical Sciences, University of New South Wales, Sydney, Australia), Andrew J. Schork (Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA), Gunter Schumann (Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom), Jean Shin (The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada), (Rotman Research Institute, University of Toronto, Toronto, M6A 2E1, Canada), Elena Shumskaya (Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands), (Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands), Sanjay Sisodiya (Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, and Chalfont Centre for Epilepsy, UK), Vidar M. Steen (NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway), (Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Jonas Lies veg 87, 5021 Bergen, Norway), Dan J. Stein (Dept of Psychiatry, University of Cape Town, Groote Schuur Hospital, Anzio Rd, 7925 Cape Town, South Africa), Stacy Steinberg (deCODE Genetics/Amgen, Reykjavik, Iceland), Lachlan Strike (Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia), Alexander Teumer (Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany), Anbu Thalamuthu (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia), Diana Tordesillas-Gutierrez (CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain), (Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, 39011, Spain), Jessica Turner (Department of Psychology, Georgia State University, Atlanta, GA), Torill Ueland (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Anne Uhlmann (Department of Psychiatry and Mental Health, Anzio Road, 7925 Cape Town, South Africa), (Department of Psychiatry, Stellenbosch University, TBH Francie van Zijl Avenue, 7500 Cape Town, South Africa), (Department of Psychiatry, 1 South Prospect Street, 5401 Burlington, Vermont, USA), Magnus O. Ulfarsson (deCODE Genetics/Amgen, Reykjavik, Iceland), (Faculty of Electrical and Computer Engineering, University of Iceland, Reykjavik, Iceland), Dennis van 't Ent (Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT Amsterdam, The Netherlands), Dennis van der Meer (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Neeltje E.M. van Haren (Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands), Anja Vaskinn (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Evangelos Vassos (MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF London, UK), G. Bragi Walters (deCODE Genetics/Amgen, Reykjavik, Iceland), Yunpeng Wang (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Wei Wen (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia), Christopher D. Whelan (Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, D02 YN77 Dublin, Ireland), Katharina Wittfeld (German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, Greifswald, Germany), Margie Wright (QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia), (Centre for Advanced Imaging, University of Queensland, St Lucia, Queensland, Australia), Hidenaga Yamamori (Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan), Tetyana Zayats (K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway), (Department of Biomedicine, University of Bergen, 5009, Bergen, Norway), Ingrid Agartz (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), Lars T. Westlye (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway), (Department of Psychology, University of Oslo, Oslo, Norway), Sébastien Jacquemont (CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada), (Department of Pediatrics, University of Montreal, Montreal H3C 3J7, Canada), Srdjan Djurovic (NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway), (Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 424 Oslo, Norway), Hreinn Stefánsson (deCODE Genetics/Amgen, Reykjavik, Iceland), Kári Stefánsson (deCODE Genetics/Amgen, Reykjavik, Iceland), (Faculty of Medicine, University of Iceland, Reykjavik, Iceland), Paul Thompson (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA), Ole A. Andreassen (NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway).es_ES
dc.format.extent19 p.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceMolecular Psychiatry, 2020, 25(3), 584-602 - (CORRECTION), 2020, 25(3), 692-695es_ES
dc.titleDose response of the 16p11.2 distal copy number variant on intracranial volume and basal gangliaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1038/s41380-018-0118-1es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1038/s41380-018-0118-1
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International