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Lung cancer survival in never-smokers and exposure to residential radon: results of the LCRINS study

dc.contributor.authorCasal-Mouriño, Ana
dc.contributor.authorRuano-Ravina, Alberto
dc.contributor.authorTorres-Durán, María
dc.contributor.authorParente-Lamelas, Isaura
dc.contributor.authorProvencio-Pulla, Mariano
dc.contributor.authorCastro-Añón, Olalla
dc.contributor.authorVidal-García, Iria
dc.contributor.authorPena-Álvarez, Carolina
dc.contributor.authorAbal-Arca, José
dc.contributor.authorPiñeiro-Lamas, María
dc.contributor.authorFuente Merino, Ismael 
dc.contributor.authorFernández-Villar, Alberto
dc.contributor.authorAbdulkader, Ihab
dc.contributor.authorValdés-Cuadrado, Luis
dc.contributor.authorBarros-Dios, Juan Miguel
dc.contributor.authorPérez-Ríos, Mónica
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2024-01-24T08:05:53Z
dc.date.available2024-01-24T08:05:53Z
dc.date.issued2020
dc.identifier.issn0304-3835
dc.identifier.urihttps://hdl.handle.net/10902/31209
dc.description.abstractWe aimed to evaluate lung cancer survival in never-smokers, both overall and specifically by sex, exposure to residential-radon, age, histological type, and diagnostic stage. We included lung cancer cases diagnosed in a multicentre, hospital-based, case-control-study of never-smoker patients, diagnosed from January-2011 to March-2015 (Lung Cancer Research In Never Smokers study). 369 never-smokers (79% women; median age 71 years; 80% adenocarcinoma; 66% stage IV) were included. Median overall survival, and at one, 3 and 5 years of diagnosis was 18.3 months, 61%, 32% and 22%, respectively. Higher median survival rates were obtained for: younger age, adenocarcinoma, actionable mutations, and earlier-stage at diagnosis. Higher indoor radon showed a higher risk of death in multivariate analysis. Median lung cancer survival in never-smokers seems higher than that in ever-smokers. Patients with actionable mutations have a significantly higher survival. Higher indoor-radon exposure has a negative effect on survivales_ES
dc.description.sponsorshipThis paper was funded by the following competitive research grants awarded to the individual case-control studies, which are part of this pooled study: Galician Regional Authority (Xunta de Galicia): 10CSA208057PR “Risk factors of lung cancer in never smokers: a multicentre case-control study in the Northwest of Spain.” 2010. Spain; Carlos III Institute of Health (Instituto de Salud Carlos III), Ministry of Science and Innovation of Spain, grant number PI03/1248. 2003. Spain; Carlos III Institute of Health (grant FIS 92/0176) and the Galician Regional Health Authority (grant XUGA 91010). 1992. Spain; Galician Regional Authority: grant number XUGA 208001B93. 1993; Carlos III Institute of Health, Ministry of Science and Innovation of Spain, grant number PI13/01765. 2013. Spain; ISCIII - PI15/01211 - Cofinanciado FEDER. Spain.es_ES
dc.description.sponsorshipThis paper was funded by the following competitive research grants awarded to the individual case-control studies, which are part of this pooled study: • Galician Regional Authority (Xunta de Galicia): 10CSA208057PR “Risk factors of lung cancer in never smokers: a multicentre case-control study in the Northwest of Spain.” 2010. Spain. • Carlos III Institute of Health (Instituto de Salud Carlos III), Ministry of Science and Innovation of Spain, grant number PI03/1248. 2003. Spain. • Carlos III Institute of Health (grant FIS 92/0176) and the Galician Regional Health Authority (grant XUGA 91010). 1992. Spain. • Galician Regional Authority: grant number XUGA 208001B93. 1993. • Carlos III Institute of Health, Ministry of Science and Innovation of Spain, grant number PI13/01765. 2013. Spain. • ISCIII - PI15/01211 - Cofinanciado FEDER. Spain.
dc.format.extent8 p.es_ES
dc.language.isoenges_ES
dc.publisherElsevier Science Irelandes_ES
dc.rights© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceCancer Letters, 2020, 487, 21-26 - (CORRIGENDUM), 2020, 493, 10es_ES
dc.subject.otherLung neoplasmses_ES
dc.subject.otherNever-smokerses_ES
dc.subject.otherIndoor radones_ES
dc.subject.otherSurvivales_ES
dc.subject.otherLung neoplasms
dc.subject.otherNever-smokers
dc.subject.otherIndoor radon
dc.subject.otherSurvival
dc.titleLung cancer survival in never-smokers and exposure to residential radon: results of the LCRINS studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1016/j.canlet.2020.05.022
dc.type.versionacceptedVersiones_ES


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