Lung cancer survival in never-smokers and exposure to residential radon: results of the LCRINS study

Casal-Mouriño, Ana; Ruano-Ravina, Alberto; Torres-Durán, María; Parente-Lamelas, Isaura; Provencio-Pulla, Mariano; Castro-Añón, Olalla; Vidal-García, Iria; Pena-Álvarez, Carolina; Abal-Arca, José; Piñeiro-Lamas, María; Fuente Merino, Ismael; Fernández-Villar, Alberto; Abdulkader, Ihab; Valdés-Cuadrado, Luis; Barros-Dios, Juan Miguel; Pérez-Ríos, Mónica

doi:10.1016/j.canlet.2020.05.022

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Identificadores

URI: https://hdl.handle.net/10902/31209

DOI: 10.1016/j.canlet.2020.05.022

ISSN: 0304-3835

Fecha

2020

Derechos

Publicado en

Cancer Letters, 2020, 487, 21-26 - (CORRIGENDUM), 2020, 493, 10

Editorial

Elsevier Science Ireland

Palabras clave

Lung neoplasms

Never-smokers

Indoor radon

Survival

Lung neoplasms

Never-smokers

Indoor radon

Survival

Resumen/Abstract

We aimed to evaluate lung cancer survival in never-smokers, both overall and specifically by sex, exposure to residential-radon, age, histological type, and diagnostic stage. We included lung cancer cases diagnosed in a multicentre, hospital-based, case-control-study of never-smoker patients, diagnosed from January-2011 to March-2015 (Lung Cancer Research In Never Smokers study). 369 never-smokers (79% women; median age 71 years; 80% adenocarcinoma; 66% stage IV) were included. Median overall survival, and at one, 3 and 5 years of diagnosis was 18.3 months, 61%, 32% and 22%, respectively. Higher median survival rates were obtained for: younger age, adenocarcinoma, actionable mutations, and earlier-stage at diagnosis. Higher indoor radon showed a higher risk of death in multivariate analysis. Median lung cancer survival in never-smokers seems higher than that in ever-smokers. Patients with actionable mutations have a significantly higher survival. Higher indoor-radon exposure has a negative effect on survival

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