| dc.contributor.author | Fernández Terán, María Ángeles | es_ES |
| dc.contributor.author | Ros Lasierra, María Ángeles | es_ES |
| dc.contributor.other | Universidad de Cantabria | es_ES |
| dc.date.accessioned | 2023-12-18T17:36:42Z | |
| dc.date.available | 2023-12-18T17:36:42Z | |
| dc.date.issued | 2008 | es_ES |
| dc.identifier.issn | 0214-6282 | es_ES |
| dc.identifier.issn | 1696-3547 | es_ES |
| dc.identifier.other | BFU2005-09309-CO2-01 | es_ES |
| dc.identifier.uri | https://hdl.handle.net/10902/30888 | |
| dc.description.abstract | The Apical Ectodermal Ridge (AER) is one of the main signaling centers during limb development. It controls outgrowth and patterning in the proximo-distal axis. In the last few years a considerable amount of new data regarding the cellular and molecular mechanisms underlying AER function and structure has been obtained. In this review, we describe and discuss current knowledge of the regulatory networks which control the induction, maturation and regression of the AER, as well as the link between dorso-ventral patterning and the formation and position of the AER. Our aim is to integrate both recent and old knowledge to produce a wider picture of the AER which enhances our understanding of this relevant structure. | es_ES |
| dc.description.sponsorship | Acknowledgements: This work was supported by grant BFU2005-09309-CO2-01 from the Spanish Ministry of Education and Science. We thank the members of our laboratory group for stimulating discussions, and specially Mª Felix Bastida for critical reading of the manuscript. We also thank Irene Delgado for Fig. 5 and Marisa Junco for excellent technical help. We are very grateful to Prof. J.M. Icardo and Borja Gallardo for help with the SEM images. | es_ES |
| dc.format.extent | 16 p. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | University of the Basque Country UPV/EHU | es_ES |
| dc.rights | © UBC Press | es_ES |
| dc.source | The International Journal of Developmental Biology, 2008, 52, 857-871 | es_ES |
| dc.subject.other | Apical ectodermal ridge | es_ES |
| dc.subject.other | AER | es_ES |
| dc.subject.other | Limb development | es_ES |
| dc.subject.other | FGF | es_ES |
| dc.subject.other | Dorso-ventral patterning | es_ES |
| dc.subject.other | Double ridge | es_ES |
| dc.title | The apical ectodermal ridge: morphological aspects and signaling pathways | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.rights.accessRights | openAccess | es_ES |
| dc.identifier.DOI | 10.1387/ijdb.072416mf | es_ES |
| dc.type.version | publishedVersion | es_ES |
