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dc.contributor.authorSalto-Alejandre, Sonsoles
dc.contributor.authorJiménez-Jorge, Silvia
dc.contributor.authorSabé, Nuria
dc.contributor.authorRamos-Martínez, Antonio
dc.contributor.authorLinares, Laura
dc.contributor.authorValerio, Maricela
dc.contributor.authorMartín Dávila, Pilar
dc.contributor.authorFernández-Ruiz, Mario
dc.contributor.authorFariñas Álvarez, María del Carmen 
dc.contributor.authorBlanes-Juliá, Marino
dc.contributor.authorVidal, Elisa
dc.contributor.authorPalacios-Baena, Zaira R.
dc.contributor.authorHernández-Gallego, Román
dc.contributor.authorCarratalá Fernández, Jordi
dc.contributor.authorCalderón-Parra, Jorge
dc.contributor.authorMarcos, María Ángeles
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorFortún-Abete, Jesús
dc.contributor.authorAugado, José María
dc.contributor.authorArnáiz de las Revillas Almajano, Francisco 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2022-04-01T15:42:38Z
dc.date.available2022-04-01T15:42:38Z
dc.date.issued2021-04-29
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/24488
dc.description.abstractThe aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant periodes_ES
dc.description.sponsorshipThis study was supported by Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016); co-financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligence Growth 2014-2020. EC and JSC received grants from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Proyectos de Investigación sobre el SARSCoV-2 y la enfermedad COVID-19 (COV20/ 00370; COV20/00580). JSC is a researcher belonging to the program “Nicola´s Monardes”(C0059–2018), Servicio Andaluz de Salud, Junta de Andalucía, Spain. SS-A is supported by a grant from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Proyectos de Investigación sobre el SARS-CoVes_ES
dc.format.extent16 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePLoS One 16(4): e0250796es_ES
dc.titleRisk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort studyes_ES
dc.title.alternativedoi.org/10.1371/journal. pone.0250796es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.1371/journal. pone.0250796es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOIdoi.org/10.1371/journal. pone.0250796
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International