Mostrar el registro sencillo

dc.contributor.authorHernández-Camba, Alejandro
dc.contributor.authorCarrillo-Palau, Marta
dc.contributor.authorRamos, Laura
dc.contributor.authorHernández Alvarez-Buylla, Noemi
dc.contributor.authorAlonso-Abreu, Inmaculada
dc.contributor.authorHernández-Pérez, Anjara
dc.contributor.authorVela, Milagros
dc.contributor.authorArranz, Laura
dc.contributor.authorHernández-Guerra, Manuel
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.authorFerraz-Amaro, Iván
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2022-03-29T15:21:27Z
dc.date.available2022-03-29T15:21:27Z
dc.date.issued2021
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10902/24435
dc.description.abstractThe addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, p = 0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (p = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02-1.04) vs. 1.01 (95%CI 1.00-1.02), interaction p = 0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients.es_ES
dc.description.sponsorshipFunding: This work was supported by a grant to I.F-A. from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016 and by Fondo Europeo de Desarrollo Regional—FEDER—(Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083).es_ES
dc.format.extent11 p.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.es_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceJ Clin Med . 2021 Apr 13;10(8):1671es_ES
dc.subject.otherInflammatory bowel diseasees_ES
dc.subject.otherSCOREes_ES
dc.subject.otherCarotid plaqueses_ES
dc.subject.otherCardiovascular riskes_ES
dc.titleCarotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Riskes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/ 10.3390/jcm10081671es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.3390/jcm10081671
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.Excepto si se señala otra cosa, la licencia del ítem se describe como © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.