Mostrar el registro sencillo

dc.contributor.authorFerraz-Amaro, Iván
dc.contributor.authorCorrales, Alfonso
dc.contributor.authorQuevedo-Abeledo, Juan Carlos
dc.contributor.authorAtienza Mateo, Belén  
dc.contributor.authorPrieta-Peña, Diana
dc.contributor.authorBlanco Alonso, Ricardo 
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2021-04-12T11:35:53Z
dc.date.available2021-04-12T11:35:53Z
dc.date.issued2020
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10902/21189
dc.description.abstractBackground: Cardiovascular (CV) disease risk prediction models developed for use in the general population have suboptimal performance in patients with rheumatoid arthritis (RA). Vascular age (VA) is a new concept that has been proposed as a measure of CV "relative" risk instead of the "absolute" risk that current prediction models provide. In the present study we aim to study the performance of vascular age (VA) in the assessment of CV risk in patients with RA. We additionally aimed to analyze its relation with subclinical atherosclerosis as measured through carotid plaque ultrasound. Methods: A total of 1173 non-diabetic RA patients without previous CV events were included. Disease characteristics, SCORE, VA determined on SCORE and on carotid intima media thickness (cIMT), and the presence of plaque through carotid ultrasound were assessed. The interrelations of VA with SCORE, and its associations with subclinical carotid atherosclerosis were studied. Results: On average, RA patients had both a SCORE determined VA (4.7 years) and a cIMT-based VA (2.4 years) significantly higher than the chronological age. When these differences were analyzed in different age intervals, while VA based on SCORE was significantly higher compared to chronological age in all age ranges, VA determined on cIMT was significantly elevated only in RA patients younger than 60 years. The area under the curve analysis for the association of SCORE and VA with the presence of carotid plaque disclosed no differences between both parameters. VA was associated with the presence of carotid plaque after multivariable regression analysis in patients younger than 60 years old. Conclusion: VA is significantly higher than chronological age in patients with RA. The performance of VA in its relation to carotid plaque is similar to that of the SCORE.es_ES
dc.description.sponsorshipThis research was funded by a grant to MAG-G from the Instituto de Salud Carlos III (ISCIII) (Fondo de Investigación Sanitaria grants PI06/0024, PI09/00748, PI12/00060, PI15/00525, PI18/00043) and the ISCIII RETICS programs (RD12/0009 and RD16/0012).es_ES
dc.format.extent9 p.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAttribution 4.0 International. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceJournal of clinical medicine 2020, 9, 4065es_ES
dc.subject.otherVascular agees_ES
dc.subject.otherRheumatoid arthritises_ES
dc.subject.otherCardiovascular risk assessmentes_ES
dc.subject.otherCarotid plaquees_ES
dc.titleThe performance of vascular age in the assessment of cardiovascular risk of patients with rheumatoid arthritises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://doi.org/10.3390/jcm9124065es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.3390/jcm9124065
dc.type.versionpublishedVersiones_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo

Attribution 4.0 International. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license