Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross-Sectional Study

Fernández-Carballido, Cristina; Martín-Martínez, María A.; García-Gómez, Carmen; Castañeda, Santos; González-Juanatey, Carlos; Sánchez-Alonso, Fernando; García de Vicuña, Rosario; Erausquin-Arruabarrena, Celia; López-Longo, Javier; Sánchez, María D.; Corrales, Alfonso; Quesada-Masachs, Estefanía; Chamizo, Eugenio; Barbadillo, Carmen; Bachiller-Corral, Javier; Cobo-Ibañez, Tatiana; Turrión, Ana; Giner, Emilio; Llorca Díaz, Francisco Javier; González-Gay Mantecón, Miguel Ángel; CARMA Project Collaborative Group

doi:10.1002/acr.23910

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Identificadores

URI: http://hdl.handle.net/10902/18628

DOI: 10.1002/acr.23910

ISSN: 2151-464X

ISSN: 2151-4658

; [et al.]

Fecha

2020-06

Derechos

© American College of Rheumatolog. Published by John Wiley & Sons. This is the peer reviewed version of the following article: Fernández-Carballido, Cristina, et al. «Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross-Sectional Study». Arthritis Care & Research, vol. 72, n.o 6, junio de 2020, pp. 822-28, which has been published in final form at doi:10.1002/acr.23910. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Publicado en

Arthritis Care Res (Hoboken) . 2020 Jun;72(6):822-828

Editorial

John Wiley & Sons

Enlace a la publicación

https://doi.org/10.1002/acr.23910

Palabras clave

Comorbidity

Physical Function

Psoriatic Arthritis

Ankylosing Spondylitis

HAQ

BASFI

Charlson Index

Resumen/Abstract

Objective: To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Methods: This was a cross-sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0-27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and P values. Results: We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (? = 0.11). Also, female sex (? = 0.14), disease duration (? = 0.01), disease activity (DAS28-ESR; ? = 0.19), and the use of nonsteroidal antiinflammatory drugs (? = 0.09), glucocorticoids (? = 0.11), and biologics (? = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (? = -0.14). In patients with AS, age (? = 0.03), disease activity (BASDAI; ? = 0.81), radiographic damage (? = 0.61), and the use of biologics (? = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. Conclusion: The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.