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dc.contributor.authorButt, Juliaes_ES
dc.contributor.authorFernández de Larrea, Nereaes_ES
dc.contributor.authorTjalsma, Haroldes_ES
dc.contributor.authorRoelofs, Rianes_ES
dc.contributor.authorKato, Ikukoes_ES
dc.contributor.authorMartín, Vicentees_ES
dc.contributor.authorPérez-Gómez, Beatrizes_ES
dc.contributor.authorMoreno, Victores_ES
dc.contributor.authorDierssen Sotos, Trinidad es_ES
dc.contributor.authorCastilla, Jesúses_ES
dc.contributor.authorFernández-Tardón, Guillermoes_ES
dc.contributor.authorAmiano, Pilares_ES
dc.contributor.authorSalas, Doloreses_ES
dc.contributor.authorAlguacil, Juanes_ES
dc.contributor.authorJiménez-Moleón, José Juanes_ES
dc.contributor.authorHuerta, José Maríaes_ES
dc.contributor.authorSanjosé, Silvia dees_ES
dc.contributor.authorCampo, Rosa deles_ES
dc.contributor.authorKogevinas, Manolises_ES
dc.contributor.authorPollán, Marinaes_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2020-01-22T16:07:28Z
dc.date.available2020-01-22T16:07:28Z
dc.date.issued2019es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/10902/17881
dc.description.abstractAntibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.es_ES
dc.description.sponsorshipWe thank Shaynoor Dramsi and Camille Danne (Department of Microbiology, Institut Pasteur, Paris, France) for providing the purified proteins Gallo2178 and Gallo2179. This work was supported by the National Institutes of Health (grant number R01-CA93817, Ikuko Kato); The Netherlands Organization for Scientific Research (NWO 016.166.089 to A.B.); the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11th October 2007; the Instituto de Salud Carlos III-FEDER funds –a way to build Europe- (grants numbers PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01662, PS09/01286, PS09/01903, PS09/02078, PI11/00226, PI11/01403, PI11/01810, PI11/01889, PI11/02213, PI12/00150, PI12/00265, PI12/00488, PI12/00715, PI12/01270, PI14/00613, PI17/00092); the Fundación Marques de Valdecilla (grant number API 10/09); Obra Social CAJASTUR (grant number SV-CAJASTUR-1); Recercaixa (grant number 2010ACUP 00310); Spanish Association Against Cancer (AECC) Scientific Foundation; Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) –Generalitat de Catalunya (Catalonian Government) (grant numbers 2009SGR1026, 2009SGR1465 and 2017SGR723); and Junta de Castilla y León (grant number LE022A10-2). Sample collection and storage was partially supported by the Instituto de Salud Carlos III-FEDER (grant number RD09/0076/00036), Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d’Oncologia de Catalunya (XBTC).es_ES
dc.format.extent7 p.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceSci Rep. 2019 Jul 26;9(1):10847es_ES
dc.titleAntibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://www.doi.org/10.1038/s41598-019-47347-6es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1038/s41598-019-47347-6es_ES
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International