Reduced antioxidant defense in early onset first-episode psychosis: a case-control study

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URI: http://hdl.handle.net/10902/1780
ISSN: 1471-244X
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Autoría
Micó, Juan Antonio; Rojas Corrales, María Olga; Gibert Rahola, Juan; Parellada, Mara; Moreno Pardillo, Dolores; Fraguas Herráez, David; Graell Berna, Montserrat; Gil Goikuria, Javier; Irazusta Astiazarán, Jon; Castro Fornieles, Josefina; Soutullo Esperón, César; Arango López, Celso; Otero Cuesta, María SorayaAutoridad Unican; Navarro, Ana; Baeza Pertegaz, Inmaculada; Martínez Cengotitabengoa, Mónica; González Pinto, Ana
Fecha
2011-02-14
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Atribución 3.0 España
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BMC Psychiatry. 2011 Feb 14;11:26
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BioMed Central
Resumen/Abstract
BACKGROUND: Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. METHODS: Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. RESULTS: A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. CONCLUSIONS: Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.
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Atribución 3.0 EspañaExcepto si se señala otra cosa, la licencia del ítem se describe como Atribución 3.0 España