Obesity, Fat Mass and Immune System: Role for Leptin

Francisco, Vera; Pino, Jesús; Campos Cabaleiro, Víctor; Ruiz Fernández, Clara; Mera, Antonio; González-Gay Mantecón, Miguel Ángel; Gómez, Rodolfo; Gualillo, Oreste

doi:10.3389/fphys.2018.00640

dc.contributor.author	Francisco, Vera
dc.contributor.author	Pino, Jesús
dc.contributor.author	Campos Cabaleiro, Víctor
dc.contributor.author	Ruiz Fernández, Clara
dc.contributor.author	Mera, Antonio
dc.contributor.author	González-Gay Mantecón, Miguel Ángel
dc.contributor.author	Gómez, Rodolfo
dc.contributor.author	Gualillo, Oreste
dc.contributor.other	Universidad de Cantabria	es_ES
dc.date.accessioned	2019-04-09T11:37:35Z
dc.date.available	2019-04-09T11:37:35Z
dc.date.issued	2018-06
dc.identifier.issn	1664-1078
dc.identifier.uri	http://hdl.handle.net/10902/16127
dc.description.abstract	Obesity is an epidemic disease characterized by chronic low-grade inflammation associated with a dysfunctional fat mass. Adipose tissue is now considered an extremely active endocrine organ that secretes cytokine-like hormones, called adipokines, either pro- or anti-inflammatory factors bridging metabolism to the immune system. Leptin is historically one of most relevant adipokines, with important physiological roles in the central control of energy metabolism and in the regulation of metabolism-immune system interplay, being a cornerstone of the emerging field of immunometabolism. Indeed, leptin receptor is expressed throughout the immune system and leptin has been shown to regulate both innate and adaptive immune responses. This review discusses the latest data regarding the role of leptin as a mediator of immune system and metabolism, with particular emphasis on its effects on obesity-associated metabolic disorders and autoimmune and/or inflammatory rheumatic diseases.	es_ES
dc.description.sponsorship	OG is Staff Personnel of Xunta de Galicia (Servizo Galego de Saude, SERGAS) through a research-staff stabilization contract (ISCIII/SERGAS). VF is a “Sara Borrell” Researcher funded by ISCIII and FEDER. RG is a “Miguel Servet” Researcher funded by Instituto de Salud Carlos III (ISCIII) and FEDER. OG, MG-G, and RG are members of RETICS Program, RD16/0012/0014 (RIER: Red de Investigación en Inflamación y Enfermedades Reumáticas) via Instituto de Salud Carlos III (ISCIII) and FEDER. The work of OG and JP (PIE13/00024 and PI14/00016, PI17/00409), and RG (PI16/01870 and CP15/00007) was funded by Instituto de Salud Carlos III and FEDER. OG is a beneficiary of a project funded by Research Executive Agency of the European Union in the framework of MSCA-RISE Action of the H2020 Program (Project No. 734899). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.	es_ES
dc.format.extent	20 p.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Frontiers Media	es_ES
dc.rights	© The authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.source	Front. Physiol. 9:640	es_ES
dc.title	Obesity, Fat Mass and Immune System: Role for Leptin	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.rights.accessRights	openAccess	es_ES
dc.identifier.DOI	10.3389/fphys.2018.00640
dc.type.version	publishedVersion	es_ES

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© The authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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