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dc.contributor.authorGómez Acebo, Inés 
dc.contributor.authorDierssen Sotos, Trinidad 
dc.contributor.authorPalazuelos Calderón, Camilo 
dc.contributor.authorFernández- Navarro, Pablo
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorAlonso Molero, Jéssica 
dc.contributor.authorUrtiaga, Carmen
dc.contributor.authorFernández-Villa, Tania
dc.contributor.authorArdanaz, Eva
dc.contributor.authorRivas-del-Fresno, Manuel
dc.contributor.authorMolina- Barceló, Ana
dc.contributor.authorJiménez Moleón, José Juan 
dc.contributor.authorGarcía Martínez, Lidia
dc.contributor.authorAmiano, Pilar
dc.contributor.authorRodríguez Cundín, María Paz 
dc.contributor.authorMoreno, Víctor
dc.contributor.authorPérez Gómez, Beatriz
dc.contributor.authorAragonés, Nuria
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorPollán, Marina
dc.contributor.authorLlorca Díaz, Francisco Javier 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2019-03-06T15:00:08Z
dc.date.available2019-03-06T15:00:08Z
dc.date.issued2018
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/15814
dc.description.abstractINTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.es_ES
dc.description.sponsorshipThis work was partially funded by the "Accion Transversal del Cancer", approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773- Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/ 01403, PI11/01889-FEDER, PI11/00226, PI11/ 01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/ 0036/0036)); The Junta de Castilla y León [LE22A10-2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224- HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo.es_ES
dc.format.extent15 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePLoS One. 2018 Aug 14;13(8):e0201750es_ES
dc.titlePigmentation phototype and prostate and breast cancer in a select Spanish population - A Mendelian randomization analysis in the MCC-Spain studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://dx.doi.org/10.1371/journal.pone.0201750es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0201750
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International