Method for predicting the therapeutic response to antipsychotic drugs

Abstract

The present invention discloses a method for predicting, before treatment, the individual clinical response to antipsychotic medication in subjects suffering from psychosis. This method is based on a gene expression profile that is useful to predict the therapeutic response to antipsychotics in drug-naïve patients. Particularly, the gene signature proposed in the invention comprises six-genes (SLC9A3, HMOX1, SLC22A16, LOC284581, PF4V1 and GSTT1) which expression profile, preferably measured in blood samples collected from the patient, provides useful information to predict the clinical response to antipsychotics in psychotic patients, more preferably in schizophrenia patients, before treatment.