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dc.contributor.authorTamayo Revuelta, Esther 
dc.contributor.authorÁlvarez Sainz de la Maza, Pilar
dc.contributor.authorMerino Pérez, Ramón 
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2019-01-08T15:02:09Z
dc.date.available2019-01-08T15:02:09Z
dc.date.issued2018-12
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.otherSAF2017-82905-Res_ES
dc.identifier.urihttp://hdl.handle.net/10902/15280
dc.description.abstractThe TGF superfamily is composed of more than 33 growth and differentiation factors, including TGF 1, 2, 3, BMPs, GDFs, nodal-related proteins, and activins. These members usually exert pleiotropic actions on several tissues and control multiple cellular processes, such as cell growth, cell survival, cell migration, cell fate specification, and differentiation, both during embryonic development and postnatal life. Although the effects of these factors on immune responses were elucidated long ago, most studies have been focused on the actions of TGF s on T cells, as major regulators of adaptive immunity. In this review, we discuss new findings about the involvement of TGF superfamily members in the control of B cell development and function. Moreover, the potential contribution of TGF signaling to control B cell-mediated autoimmune diseases and its utility in the design of new therapies are also discussed.es_ES
dc.description.sponsorshipFunding: This work was supported by a grant from the Spanish Ministerio de Economía y Competitividad to RM (SAF2017-82905-R), which was co-funded by the European Regional Development Fundes_ES
dc.format.extent18 p.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAttribution 4.0 Internationales_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceInt. J. Mol. Sci. Volume 19, Issue 12, December 2018, Article number 3928es_ES
dc.subject.otherTGF_ superfamilyes_ES
dc.subject.otherTGF_ signalinges_ES
dc.subject.otherB Celles_ES
dc.subject.otherImmune Homeostasises_ES
dc.subject.otherTolerancees_ES
dc.subject.otherAutoimmunityes_ES
dc.titleTGFB superfamily members as regulators of B cell development and function-implications for autoimmunityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherVersionhttps://dx.doi.org/10.3390/ijms19123928es_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.3390/ijms19123928
dc.type.versionpublishedVersiones_ES


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Attribution 4.0 InternationalExcepto si se señala otra cosa, la licencia del ítem se describe como Attribution 4.0 International