The effects of tobacco smoking on age of onset of psychosis and psychotic symptoms in a first-episode psychosis population

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URI: http://hdl.handle.net/10902/13718
ISSN: 0965-2140
ISSN: 1360-0443
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Autoría
Hickling, Lauren M.; Ortiz García de la Foz, Victor; Ayesa Arriola, RosaAutoridad Unican; Crespo Facorro, BenedictoAutoridad Unican; McGuire, Philip; Pérez Iglesias, Rocío
Fecha
2017-03
Derechos
© Society for the Study of Addiction. Published by Wiley. This is the peer reviewed version of the following article: Hickling, Lauren M., et al. The Effects of Tobacco Smoking on Age of Onset of Psychosis and Psychotic Symptoms in a First-Episode Psychosis Population: First-Episode Psychosis, Onset Age and Smoking. Addiction, vol. 112, n.o 3, marzo de 2017, pp. 526-32. doi:10.1111/add.13646., which has been published in final form at https://dx.doi.org/10.1111/add.13646. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
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Addiction. 2017 Mar;112(3):526-532
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Society for the Study of Addiction
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Palabras clave
Age of Onset
First-Episode Psychosis
Psychopathology
Psychosis
Smoking
Tobacco
Resumen/Abstract
BACKGROUND AND AIMS: Research suggests that tobacco smokers may develop psychosis at an earlier age than non-smokers, with effects on psychotic symptoms. We aimed to test the difference in age of onset of psychosis between smokers and non-smokers. DESIGN: Self-report data were collected from smokers and non-smokers in a population of first-episode psychosis patients. SETTING: Out-patient first-episode psychosis programme in Santander (Cantabria), Spain. PARTICIPANTS: Three hundred and ninety-seven patients (226 male, 171 female) who agreed to take part between 2001 and 2011. MEASUREMENTS: Age of onset of psychosis, age of smoking initiation, demographics, family history of psychosis and cannabis use were collected by self-report. FINDINGS: Kaplan-Meier analysis showed that smokers had a significantly lower mean age of psychosis onset [smokers = 27.4 (± 8.1) years, non-smokers = 30.5 (± 9.9) years] than non-smokers (?2(1) = 11.72, P = 0.001). The Cox proportional hazard model showed no significant difference in the age of psychosis onset between smokers and non-smokers adjusted for covariates [hazard ratio (HR) = 1.034, 95% confidence interval (CI) = 0.828-1.291]. Age of psychosis onset was predicted significantly by cannabis use (HR = 2.073, 95% CI = 1.633-2.633) and gender (HR = 1.706, 95% CI = 1.363-2.135). CONCLUSIONS: Smokers do not appear to have a significantly earlier age of psychosis onset than non-smokers after taking into account cannabis use and gender.
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