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dc.contributor.authorLópez Mejías, Raqueles_ES
dc.contributor.authorCorrales Martínez, Alfonsoes_ES
dc.contributor.authorVicente, Estheres_ES
dc.contributor.authorRobustillo Villarino, Montserrates_ES
dc.contributor.authorGonzález Juanatey, Carloses_ES
dc.contributor.authorLlorca Díaz, Francisco Javier es_ES
dc.contributor.authorGenre, Fernandaes_ES
dc.contributor.authorRemuzgo Martínez, Saraes_ES
dc.contributor.authorDierssen Sotos, Trinidad es_ES
dc.contributor.authorMiranda Filloy, José Albertoes_ES
dc.contributor.authorRamírez Huaranga, Marco A.es_ES
dc.contributor.authorPina Murcia, Trinitarioes_ES
dc.contributor.authorBlanco Alonso, Ricardo es_ES
dc.contributor.authorAlegre Sancho, Juan J.es_ES
dc.contributor.authorRaya, Enriquees_ES
dc.contributor.authorMijares Díaz, Verónica es_ES
dc.contributor.authorUbilla García, Begoñaes_ES
dc.contributor.authorFerraz Amaro, Ivánes_ES
dc.contributor.authorOcejo Viñals, Javier Gonzaloes_ES
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel es_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2018-01-22T17:47:50Z
dc.date.available2018-01-22T17:47:50Z
dc.date.issued2017-01-06es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/10902/12909
dc.description.abstractA genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.es_ES
dc.format.extent6 p.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsCreative Commons Attribution 4.0 International License © The Author(s) 2017es_ES
dc.sourceSci Rep. 2017 Jan 6;7:40303es_ES
dc.titleInfluence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1038/srep40303es_ES
dc.type.versionpublishedVersiones_ES


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