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dc.contributor.authorLope, Virginiaes_ES
dc.contributor.authorFernández de Larrea, Nereaes_ES
dc.contributor.authorPérez Gómez, Beatrizes_ES
dc.contributor.authorMartín, Vicentees_ES
dc.contributor.authorMoreno, Victores_ES
dc.contributor.authorCostas, Lauraes_ES
dc.contributor.authorLongo, Federicoes_ES
dc.contributor.authorJiménez Moleón, José Juan es_ES
dc.contributor.authorLlorca Díaz, Francisco Javier es_ES
dc.contributor.authorAscunce, Nieveses_ES
dc.contributor.authorPeiró Pérez, Rosanaes_ES
dc.contributor.authorAltzibar, Jone Mes_ES
dc.contributor.authorTardón García, Adoninaes_ES
dc.contributor.authorAlguacil Ojeda, Juanes_ES
dc.contributor.authorNavarro, Carmenes_ES
dc.contributor.authorSierra, Angeleses_ES
dc.contributor.authorVega, Ana Belénes_ES
dc.contributor.authorVillafañe, Amayaes_ES
dc.contributor.authorCastaño Vinyal, Gemmaes_ES
dc.contributor.authorKogevinas, Manolises_ES
dc.contributor.authorPollán, Marinaes_ES
dc.contributor.authorAragonés, Nuriaes_ES
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2017-06-12T11:32:55Z
dc.date.available2017-06-12T11:32:55Z
dc.date.issued2016es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/10902/11211
dc.description.abstractBACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models. RESULTS: Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed. CONCLUSION: These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear.es_ES
dc.format.extent16 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourcePLoS One. 2016 Oct 24;11(10):e0164620es_ES
dc.titleMenstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spaines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0164620es_ES
dc.type.versionpublishedVersiones_ES


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Atribución 3.0 EspañaExcepto si se señala otra cosa, la licencia del ítem se describe como Atribución 3.0 España