Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract

Martínez-López, Azahara; Montes Moreno, Santiago; Ramos, Rafael; Afonso-Martín, Juan Luis; Mazorra Macho, Francisco; González de Villambrosía, Sonia; Batllé López, Ana; Grogan, Thomas M.; Piris Pinilla, Miguel Ángel

doi:10.1111/his.12511

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Identificadores

URI: http://hdl.handle.net/10902/10721

DOI: 10.1111/his.12511

ISSN: 1365-2559

ISSN: 0309-0167

Fecha

2014-10-30

Derechos

© Wiley This is the peer reviewed version of the following article: Histopathology Volume 65, Issue 6, Dec 2014, Pages 805–813, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/his.12511/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."

Publicado en

Histopathology Volume 65, Issue 6, 2014 Pages 805–813

Editorial

Wiley

Enlace a la publicación

http://onlinelibrary.wiley.com/doi/10.1111/his.12511/full

Resumen/Abstract

Aims Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders. Methods and results Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations. Conclusions Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.