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dc.contributor.authorCenit, Maria Carmen
dc.contributor.authorMartínez Florensa, Mario
dc.contributor.authorConsuegra, Marta
dc.contributor.authorBonet, Lizette
dc.contributor.authorCarnero Montoro, Elena
dc.contributor.authorArmiger, Noelia
dc.contributor.authorCaballero Baños, Miguel
dc.contributor.authorArias, Maria Teresa
dc.contributor.authorBenitez, Daniel
dc.contributor.authorOrtego Centeno, Norberto
dc.contributor.authorRamón Garrido, Enrique de
dc.contributor.authorSabio, José Mario
dc.contributor.authorGarcía Hernández, Francisco J.
dc.contributor.authorTolosa, Carles
dc.contributor.authorSuárez, Ana
dc.contributor.authorGonzález-Gay Mantecón, Miguel Ángel 
dc.contributor.authorBosch, Elena
dc.contributor.authorMartín, Javier
dc.contributor.authorLozano, Francisco
dc.contributor.otherUniversidad de Cantabriaes_ES
dc.date.accessioned2017-01-26T17:43:11Z
dc.date.available2017-01-26T17:43:11Z
dc.date.issued2014-11
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10902/10171
dc.description.abstractOBJECTIVE: CD5 plays a crucial role in autoimmunity and is a well-established genetic risk factor of developing RA. Recently, evidence of positive selection has been provided for the CD5 Pro224-Val471 haplotype in East Asian populations. The aim of the present work was to further analyze the functional relevance of non-synonymous CD5 polymorphisms conforming the ancestral and the newly derived haplotypes (Pro224-Ala471 and Pro224-Val471, respectively) as well as to investigate the potential role of CD5 on the development of SLE and/or SLE nephritis. METHODS: The CD5 SNPs rs2241002 (C/T; Pro224Leu) and rs2229177 (C/T; Ala471Val) were genotyped using TaqMan allelic discrimination assays in a total of 1,324 controls and 681 SLE patients of Spanish origin. In vitro analysis of CD3-mediated T cell proliferative and cytokine response profiles of healthy volunteers homozygous for the above mentioned CD5 haplotypes were also analyzed. RESULTS: T-cell proliferation and cytokine release were significantly increased showing a bias towards to a Th2 profile after CD3 cross-linking of peripheral mononuclear cells from healthy individuals homozygous for the ancestral Pro224-Ala471 (CC) haplotype, compared to the more recently derived Pro224-Val471 (CT). The same allelic combination was statistically associated with Lupus nephritis. CONCLUSION: The ancestral Ala471 CD5 allele confers lymphocyte hyper-responsiveness to TCR/CD3 cross-linking and is associated with nephritis in SLE patients.es_ES
dc.format.extent9 p.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourcePLoS One. 2014 Nov 17;9(11):e113090es_ES
dc.titleAnalysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsopenAccesses_ES
dc.identifier.DOI10.1371/journal.pone.0113090
dc.type.versionpublishedVersiones_ES


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Atribución 3.0 EspañaExcepto si se señala otra cosa, la licencia del ítem se describe como Atribución 3.0 España