@article{10902/9265,
year = {2016},
url = {http://hdl.handle.net/10902/9265},
abstract = {Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age‐measures (DmAM) were used: the multi‐tissue age estimator for cartilage and bone; and a blood‐specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95 % CI = 1.1 to 6.3, P = 0.008) of OA patients. By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95 % CI = ‐1.8 to 1.9, P = 0.3) and in blood (‐0.6 years; 95 % CI = ‐1.5 to 0.3, P = 0.2) between OA patients and controls. Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.},
publisher = {Impact Journals, LLC},
publisher = {Aging (Albany NY). 2016 Sep 28;8(9):2222-2231},
title = {Specific premature epigenetic aging of cartilage in osteoarthritis},
author = {Vidal Bralo, L and López Golán, Y and Mera Varela, A and Rego Pérez, Ignacio and Horvath, S and Zhang, Y and Real Bolt, Álvaro del and Zhai, G and Blanco, FJ and Riancho Moral, José Antonio and Gómez Reino, JJ and González, A},
}