@article{10902/9187,
year = {2016},
url = {http://hdl.handle.net/10902/9187},
abstract = {Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.},
publisher = {Nature Publishing Group},
publisher = {Sci Rep. 2016 Aug 18;6:31979},
title = {Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis},
author = {López Mejías, Raquel and Genre, Fernanda and Remuzgo Martínez, Sara and González Juanatey, Carlos and Robustillo Villarino, M. and Llorca Díaz, Francisco Javier and Corrales, A. and Vicente, E. and Miranda Filloy, José Alberto and Magro, C. and Tejera Segura, B. and Ramírez Huaranga, Marco A. and Pina Murcia, Trinitario and Blanco Alonso, Ricardo and Alegre Sancho, JJ. and Raya, E. and Mijares, V. and Ubilla, B. and Mínguez Sánchez, MD. and Gómez Vaquero, C. and Balsa Criado, Alejandro and Pascual Salcedo, D. and López Longo, FJ. and Carreira, P. and González Álvaro, Isidoro and Rodríguez Rodríguez, Luis and Fernández Gutiérrez, Benjamín and Ferraz Amaro, I. and Castañeda, S. and Martín, J. and González-Gay Mantecón, Miguel Ángel},
}