@article{10902/7931,
year = {2015},
month = {11},
url = {http://hdl.handle.net/10902/7931},
abstract = {OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.71 ± 0.14 mm versus 0.76 ± 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean ± SD: 0.73 ± 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean ± SD: 0.72 ± 0.16 mm versus 0.75 ± 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.},
publisher = {Public Library of Science},
publisher = {PLoS One. 2015 Nov 16;10(11):e0143153},
title = {Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients},
author = {López Mejías, Raquel and Genre, Fernanda and Remuzgo Martínez, Sara and Robustillo Villarino, Montserrat and García Bermúdez, Mercedes and Llorca Díaz, Francisco Javier and Corrales Martínez, Alfonso and González Juanatey, Carlos and Ubilla García, Begoña and Miranda Filloy, José Alberto and Mijares Díaz, Verónica and Pina Murcia, Trinitario and Blanco Alonso, Ricardo and Alegre Sancho, Juan J. and Ramírez Huaranga, Marco A. and Mínguez Sánchez, María D. and Tejera Segura, Beatriz and Ferraz Amaro, Iván and Vicente-Rabaneda, Esther and Carmona, F. David and Castañeda Sanz, Santos and Martín Ibáñez, Javier and González-Gay Mantecón, Miguel Ángel},
}