@article{10902/6221,
year = {2015},
month = {3},
url = {http://hdl.handle.net/10902/6221},
abstract = {We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient. Observations in these cases imply that considering not only the number of mutations but an effective oncogenic combination of mutations can determine the malignant progression of colorectal lesions.},
publisher = {Public Library of Science},
publisher = {PLoS One. 2015 Mar 16;10(3):e0119946},
title = {Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens},
author = {Vaqué Díez, José Pedro and Martínez Magunacelaya, Nerea and Varela Egocheaga, Ignacio and Fernández Fernández, Fidel Ángel and Mayorga Fernández, Marta and Derdak, Sophia and Beltrán, Sergi and Moreno Rodríguez, Thaidy and Almaraz Pro, Carmen and Heras Castaño, Gonzalo de las and Bayés, Mónica and Gut, Ivo and Crespo García, Javier and Piris Pinilla, Miguel Ángel},
}