@article{10902/6216,
year = {2015},
month = {3},
url = {http://hdl.handle.net/10902/6216},
abstract = {Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.},
organization = {Acknowledgments The authors wish to thank all the patients with RA that participated to make this study possible. We want to specially thank Rodrigo Ochoa, Sofía Vargas, M. Luisa Lopez, M. Jesus Ibañez, and Sara Olavarria for their technical assistance. This study was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (Grants ´ PI06/0024, PS09/00748, and PI12/00060) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009/0013 and RD12/0009/0004 (RIER) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain), and in part by grants from the European IMI BTCure Program. Mercedes García-Bermudez is a beneficiary of a grant from Fundación Española de Reumatología (FER). Raquel Lopez-Mejías is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto Carlos III de Salud at the Spanish Ministry of Health (Spain) (CD12/00425). Fernanda Genre and Begoña Ubilla are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).},
publisher = {Hindawi Publishing Corporation},
publisher = {Biomed Research International. 2015;2015:318364},
title = {Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis},
author = {García Bermúdez, Mercedes and López Mejías, Raquel and Genre, Fernanda and Castañeda Sanz, Santos and Corrales Martínez, Alfonso and Llorca Díaz, Francisco Javier and González Juanatey, Carlos and Ubilla García, Begoña and Mirando Filloy, José Alberto and Pina Murcia, Trinitario and Gómez Vaquero, Carmen and Rodríguez Rodríguez, Luis and Fernández Gutiérrez, Benjamín and Balsa Criado, Alejandro and Pascual Salcedo, Dora and López Longo, Francisco J. and Carreira Delgado, Patricia and Blanco Alonso, Ricardo and Martín Ibáñez, Javier and González-Gay Mantecón, Miguel Ángel},
}