@article{10902/6190,
year = {2011},
month = {9},
url = {http://hdl.handle.net/10902/6190},
abstract = {Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cases and 10 132 controls from Caucasian ancestry using Rochester (USA) incidence data. At the age of 85 the LTR of AD without reference to APOE genotype was 11% in males and 14% in females. At the same age, this risk ranged from 51% for APOE44 male carriers to 60% for APOE44 female carriers, and from 23% for APOE34 male carriers to 30% for APOE34 female carriers, consistent with semi-dominant inheritance of a moderately penetrant gene. Using PAQUID (France) incidence data, estimates were globally similar except that at age 85 the LTRs reached 68 and 35% for APOE 44 and APOE 34 female carriers, respectively. These risks are more similar to those of major genes in Mendelian diseases, such as BRCA1 in breast cancer, than those of low-risk common alleles identified by recent GWAS in complex diseases. In addition, stratification of our data by age groups clearly demonstrates that APOE4 is a risk factor not only for late-onset but for early-onset AD as well. Together, these results urge a reappraisal of the impact of APOE in Alzheimer disease.},
publisher = {Nature Publishing Group},
publisher = {Molecular Psychiatry. 2011 Sep;16(9):903-7},
title = {APOE and Alzheimer disease: a major gene with semi-dominant inheritance},
author = {Genin, Emmanuelle and Hannequin, Didier and Wallon, David and Sleegers, Kristel and Hiltunen, Mikko and Combarros Pascual, Onofre and Bullido, María Jesús and Brouwers, Nathalie and Bettens, Karolien and Berr, Claudine and Pasquier, Florence and Dubois, Bruno and DeKosky, Steven T. and Tognoni, Gloria and Fiévet, Nathalie and Engelborghs, Sebastiaan and Arosio, Beatrice and Coto García, Elicer and Deyn, Peter De and Zompo, Maria Del and Mateo Fernández, José Ignacio and Epelbaum, Jacques and Frank García, Ana and Helisalmi, Seppo and Porcellini, Elisa and Pilotto, Alberto and Forti, Paola and Ferri, Raffaele and Scarpini, Elio and Siciliano, Gabriele and Solfrizzi, Vincenzo and Sorbi, Sandro and Spalletta, Gianfranco and Ravaglia, Giovanni and Valdivieso Amato, Fernando and Vepsäläinen, Saila and Álvarez, Victoria and Bosco, Paolo and Mancuso, Michelangelo and Panza, Francesco and Nacmias, Benedetta and Bossù, Paola and Hanon, Olivier and Piccardi, Paola and Annoni, Giorgio and Seripa, Davide and Galimberti, Daniela and Licastro, Federico and Soininen, Hilkka and Dartigues, Jean-François and Tzourio, Christophe and Van Broeckhoven, Christine and Kamboh, M. Ilyas and Alpérovitch, Annick and Lambert, Jean Charles and Amouyel, Philippe and Campion, Dominique},
}