@article{10902/5737,
year = {2012},
month = {12},
url = {http://hdl.handle.net/10902/5737},
abstract = {Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population.},
organization = {This work was partly supported by Grants PI05-0503 and G03-104 to F. Leyva-Cobián and Grant PI04-1086 to M. Carmen Fariñas. from the Fondo de Investigaciones Sanitarias (Ministry of Health, Spain). All authors read and approved the final version of the paper for publication.},
publisher = {Hindawi Publishing Corporation},
publisher = {Pulmonary Medicine. 2012;2012:469128},
title = {Mannose-binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from Cantabria (northern Spain)},
author = {Ocejo Vinyals, Javier Gonzalo and Lavín Alconero, Lucía and Sánchez Velasco, Pablo and Guerrero Alonso, María Ángeles and Ausín, Fernando and Fariñas Álvarez, María del Carmen and Leyva y Cobián, Francisco Juan},
}