@article{10902/534,
year = {2011},
month = {7},
url = {http://hdl.handle.net/10902/534},
abstract = {Introduction
Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients. 

Methods
A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a predesigned TaqMan SNP genotyping assay. Classical ACP1 alleles (*A, *B and *C) were imputed with SNP data. 

Results
No association between ACP1 gene polymorphisms and susceptibility to RA was observed. However, when RA patients were stratified according to the presence or absence of CV events, an association between rs11553742*T and CV events was found (P = 0.012, odds ratio (OR) = 2.62 (1.24 to 5.53)). Likewise, the ACP1*C allele showed evidence of association with CV events in patients with RA (P = 0.024, OR = 2.43). 

Conclusions
Our data show that the ACP1*C allele influences the risk of CV events in patients with RA.},
organization = {We thank Sofía Vargas, Sonia Rodríguez and Rodrigo Ochoa for their
excellent technical assistance, and Mercedes García Bermudez for her
comments in the analysis of CV events. We thank Banco Nacional de
ADN (University of Salamanca, Spain), which supplied part of the control
DNA samples, and we thank all patients and donors for their
collaboration.
This work was supported by two grants from Fondo de Investigaciones
Sanitarias PI06-0024 and PS09/00748 (Spain) and by the RETICS Program,
RD08/0075 (RIER) from the Instituto de Salud Carlos III (ISCIII), within the VI
PN de I+D+i 2008-2011 (FEDER). MT was supported by the Spanish Ministry
of Science through the program Juan de la Cierva (JCI-2010-08227).},
publisher = {BioMed Central},
publisher = {Arthritis Research & Therapy, 2011, 13:R116},
title = {Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients},
author = {Teruel, María and Martín, José Ezequiel and González Juanatey, Carlos and López Mejías, Raquel and Miranda Filloy, José Alberto and Blanco Alonso, Ricardo and Balsa Criado, Alejandro and Pascual Salcedo, Dora and Rodríguez Rodríguez, Luis and Fernández Gutiérrez, Benjamín and Ortiz, Ana M. and González Álvaro, Isidoro and Gómez Vaquero, Carmen and Bottini, Nunzio and Llorca Díaz, Javier and González-Gay Mantecón, Miguel Ángel and Martín Ibáñez, Javier},
}