@article{10902/4671,
year = {2014},
month = {3},
url = {http://hdl.handle.net/10902/4671},
abstract = {Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.},
organization = {Acknowledgments. The authors wish to thank all the patients with RA that participated to make this study possible. We want to specially thank Rodrigo Ochoa, SofÍa Vargas, M. Luisa López, M. Jesus Ibañez, and Sara Olavarria for their technical assistance. 
This study was supported by European Union FEDER Funds and “Fondo de Investigación Sanitaria” (Grants PI06/0024, PS09/00748, and PI12/00060) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009/0013 and RD12/0009/0004 (RIER) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain) and in part by grants from the European IMI BTCure Program. Raquel Lopez-Mejías is a recipient of Sara Borrell postdoctoral fellowship from the Instituto Carlos III de Salud at the Spanish Ministry of Health (Spain) (CD12/00425). Fernanda Genre and Begoña Ubilla 
are supported by Funds from the RETICS Program (RIER) (RD12/0009/0013). Mercedes García-Bermúdez is a beneficiary of a grant from Fundación Española de Reumatología (FER).},
publisher = {Hindawi Publishing Corporation},
publisher = {Mediators of Inflammation. 2014;2014:756279. Epub 2014 Mar 25},
title = {Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis},
author = {López Mejías, Raquel and Genre, Fernanda and García Bermúdez, Mercedes and Ubilla García, Begoña and Castañeda Sanz, Santos and Llorca Díaz, Francisco Javier and González Juanatey, Carlos and Corrales Martínez, Alfonso and Miranda Filloy, José Alberto and Pina Murcia, Trinitario and Gómez Vaquero, Carmen and Rodríguez Rodríguez, Luis and Fernández Gutiérrez, Benjamín and Balsa Criado, Alejandro and Pascual Salcedo, Dora and López Longo, Francisco J. and Carreira Delgado, Patricia and Blanco Alonso, Ricardo and Martín Ibáñez, Javier and González-Gay Mantecón, Miguel Ángel},
}