@article{10902/4048,
year = {2013},
month = {10},
url = {http://hdl.handle.net/10902/4048},
abstract = {Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. Previous genome-wide association studies have described SMAD3 rs17228212 polymorphism as an important signal associated with CV events. The aim of the present study was to evaluate for the first time the relationship between this gene polymorphism and the susceptibility to CV manifestations and its potential association with the presence of subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in patients with RA.},
organization = {This study was supported by grants from “Fondo de Investigaciones Sanitarias” PS09/00748 and PI12/00060 (Spain). This work was also partially supported by RETICS Program (RIER) RD12/0009/0013 and RD12/0009/0004 from “Instituto de Salud Carlos III” (ISCIII) (Spain). This work was supported in part by grants from the European IMI BTCure Program. MGB is a beneficiary of a grant from Fundación Española de Reumatología (FER). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain). FG is supported by funds from the RETICS Program (RIER). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.},
publisher = {Public Library of Science},
publisher = {PLoS One, 2013, 8(10), e77695},
title = {SMAD3 rs17228212 gene polymorphism is associated with reduced risk to cerebrovascular accidents and subclinical atherosclerosis in anti-CCP negative Spanish rheumatoid arthritis patients},
author = {García Bermúdez, Mercedes and López Mejías, Raquel and Genre, Fernanda and Castañeda Sanz, Santos and González Juanatey, Carlos and Llorca Díaz, Francisco Javier and Corrales Martínez, Alfonso and Miranda Filloy, José Alberto and Rueda Gotor, Javier and Gómez Vaquero, Carmen and Rodríguez Rodríguez, Luis and Fernández Gutiérrez, Benjamín and Pascual Salcedo, Dora and Balsa Criado, Alejandro and López Longo, Francisco J. and Carreira Delgado, Patricia and Blanco Alonso, Ricardo and González Álvaro, Isidoro and Martín Ibáñez, Javier and González-Gay Mantecón, Miguel Ángel},
}