@article{10902/38507,
year = {2025},
url = {https://hdl.handle.net/10902/38507},
abstract = {Statin exposure has been associated with a broad spectrum of muscle toxicity, ranging from asymptomatic creatine kinase (CK) elevation to immune-mediated necrotizing myopathy (IMNM) with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies. The mechanisms underlying these adverse effects are not fully understood, and genetic predisposition may play a role. This observational study evaluated the association of HLA-DRB1*11 and SLCO1B1 rs4149056 variants with statin-induced muscle toxicity. A total of 62 statin-exposed patients treated at a single tertiary center were included and classified as follows: IMNM with anti-HMGCR antibodies (n = 11), non-immune myotoxicity (n = 20), and statin-exposed controls without myopathy (n = 31). The mean age was 66 ± 7.5 years, and 62% were women. The frequency of the HLA-DRB1*11 allele was significantly higher in patients with anti-HMGCR IMNM compared to those with non-immune myotoxicity (81.0% vs. 25.0%; OR = 13.5, 95% CI 1.73?15.3; p < 0.01) and controls (81.0% vs. 17.2%; OR = 21.6, 95% CI 2.87?23.7; p < 0.01). No significant difference was found between the non-immune myotoxicity and control groups. Likewise, the SLCO1B1 rs4149056 variant showed no association with either IMNM or non-immune muscle toxicity. These findings confirm a strong association between the HLA-DRB1*11 allele and anti-HMGCR IMNM. This genetic marker may help to better distinguish immune-mediated from non-immune forms of statin-related myopathy.},
publisher = {MDPI},
publisher = {International Journal of Molecular Sciences, 2025, 26(22), 11144},
title = {Genetic biomarkers for statin-induced myopathy},
author = {Prieto Peña, Diana and Urriago Gil, Juan David and Ocejo Viñals, Javier Gonzalo and García Ibarbia, María del Carmen and Salmón González, Zaida and Martín Millán, Marta and Corrales Selaya, Cristina and Pulito Cueto, Verónica and López Mejías, Raquel and Blanco Alonso, Ricardo and Hernández Hernández, José Luis},
}