@article{10902/38506,
year = {2025},
url = {https://hdl.handle.net/10902/38506},
abstract = {Introduction: Inthis retrospective study, withprolongedfollow-up, we analyze the outcomes of allogeneic
hematopoietic stem cell transplantation (allo-HSCT) in adult acute lymphoblastic leukemia (ALL) and the
impact of pre-transplantation measurable residual disease (pre-HSCT MRD).
Methods: Detection of MRD was performed by multiparametric flow cytometry (MFC) for Philadelphia
chromosome-negative ALL (Ph-neg ALL) and by classic genetic tests for Ph-pos ALL.
Results: Among 46 patients in first complete remission (CR1) who had available MRD data, 1- and 3-year cumulative incidences of relapse (CIR) for patients with positive and negative MRD were 47.1% and 52.9% vs. 3.4% and 6.9%, respectively (p < 0.001). Disease free survival (DFS) at 1 and 3 years was 82.8% (95% CI 70.1–97.7) and 79.3% (95% CI 65.9–95.5) in the negative MRD group and 35.3% (95% CI 18.5–67.2) and 29.4% (95% CI 14.1–61.4) in the positive MRD group (p < 0.001). With a median follow up of 29 months in the entire cohort and 177.6 months (14.8 years) in survivors, 1- and 3-year overall survival (OS) for the pre-HSCT negative MRD group was 82.8% (95% CI 70.1–97.7) and 79.2% (95% CI 65.6–95.5), respectively, compared to 64.7% (95% CI 45.5–91.9) and 41.2% (95% CI 23.3–72.7) in the positive MRD group (p = 0.001). In a multivariate model, positive pre-HSCT MRD is associated with increased CIR and poorer DFS and OS. Conclusion: These results support that pre-HSCT MRD should be eradicated to improve survival of adult ALL patients who undergo allo-HSCT.},
publisher = {Elsevier},
publisher = {Medicina clínica},
title = {Importance of measurable residual disease in the outcome of adults with acute lymphoblastic leukemia after allogeneic stem cell transplantation: long follow-up analysis from a single transplant center},
author = {Ormazabal Vélez, Irati and Galbete Jiménez, Arkaitz and Sánchez Escamilla, Miriam and Marcos Jiménez, Ana and Fernández Ruiz, Elena and Salmanton García, Jon and Bermúdez Rodríguez, María Aranzazu and Figuera Álvarez, Ángela},
}