@article{10902/37852,
year = {2025},
url = {https://hdl.handle.net/10902/37852},
abstract = {Purpose: To evaluate the long-term oncological outcomes and toxicity profile based on 24 years of follow-up in patients with localized very high-risk prostate cancer (VHR PCa) treated with a combination of high-dose-rate brachytherapy (HDR-BT) and pelvic external beam radiation therapy (EBRT). 
Methods: A retrospective analysis was conducted on 87 patients with VHR PCa, classified according to National Comprehensive Cancer Network (NCCN) criteria, who received HDR-BT and EBRT. Androgen deprivation therapy (ADT) was administered to 72 patients (82.8%). The primary endpoints were biochemical control and cancer-specific survival (CSS), while the secondary endpoints included local control rates, tumor-free survival (TFS), overall survival (OS), and treatment-related toxicity. 
Results: The 24-year biochemical control rate was 68% (standard deviation [SD]: ±4%), while CSS and TFS at 24 years were 82% (SD ±4%) and 78% (SD ±4%), respectively. Local control rates remained at 98% at 24 years. Furthermore, the OS rate at 24 years was 30%. Multivariate Cox regression analysis identified the T category in the TNM classification as the only factor significantly associated with biochemical control, with 24-year rates of 69%, 71%, and 50% for patients with T-classifications of ?T2c, T3a, and T3b-T4, respectively (p = 0.024). Notably, no grade ?3 late toxicities were observed during the follow-up period. 
Conclusions: The 24-year outcomes support the viability and therapeutic efficacy of EBRT combined with a conformal HDR-BT boost for patients with VHR PCa},
publisher = {MDPI},
publisher = {Biomedicines, 2025, 13(6), 1310},
title = {Long-Term outcomes after high-dose-rate brachytherapy and hypofractionated external beam radiotherapy in very high-risk prostate cancer: a 24-year follow-up},
author = {Prada Gómez, Pedro and Rivero Pérez, Ana Laura and Carballido Rodríguez, Joaquín and Anchuelo Latorre, Javier Tomás and Fabregat Borrás, Rosa and Gutiérrez Ruiz, Marina and Rodríguez Acosta Caballero, Cristina and Carrascal Gordillo, Carlos F. and Galdós Barroso, María Piedad and Navarrete Solano, Paola Andrea},
}