@article{10902/37796,
year = {2025},
url = {https://hdl.handle.net/10902/37796},
abstract = {We performed a retrospective multicenter study including 791 patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) who underwent autologous stem cell transplantation (ASCT). After a median follow-up of 74 months from infusion, 65% were alive and 84% free of disease. Progression-free survival (PFS) and overall survival (OS) at 6 years were 51% and 63%, respectively. Non-relapse mortality at 1 year was 9%. Age >60 years at ASCT (hazard ratio [HR], 1.31; 95% CI, 1.06-1.62; P = .011), ASCT as 3rd line (HR, 1.81; 95% CI, 1.42-2.31; P < .001), and partial response (PR) vs complete response (CR) at ASCT (HR, 1.46; 95% CI. 1.18-1.81; P < .001) were independent variables influencing PFS. Age >60 years at ASCT (HR, 1.62; 95% CI, 1.24-2.12; P < .001), time period before 1 November 2012 (HR, 1.40; 95% CI, 1.07-1.83; P = .014), ASCT as ?3rd line (HR, 1.77; 95% CI, 1.32-2.37; P < .001), PR vs CR (HR, 1.58; 95% CI, 1.22-2.05; P < .001), and stable disease vs CR pre-ASCT (HR, 3.41; 95% CI, 1.81-6.45; P < .001) were variables associated with worse OS. Refractory/early relapse did not significantly influence survival (6-year PFS and OS in patients with refractory, early, and late relapse were 54% and 64%, 46% and 62%, and 49% and 63%, respectively). To our knowledge, this is the largest series analyzing the efficacy of ASCT in patients with R/R LBCL after rituximab-containing frontline therapy. Our results indicate that ASCT is a curative option for patients with chemosensitive disease.},
publisher = {American Society of Hematology},
publisher = {Blood Advances, 2025, 9(13), 3281-3292},
title = {Autologous stem cell transplantation for relapsed/refractory large B-cell lymphoma: a multicenter GETH-TC/GELTAMO study},
author = {Bento, Leyre and Gutiérrez, Antonio and Martínez, Carmen and Consejo Ortí Verdet, María and Sorribes, Marina and Caballero, Ana Carolina and Peña, Marta and Pérez, Ariadna and Jiménez-Ubieto, Ana and Medina, Lucía and Bastos-Oreiro, Mariana and Caldas González, Paula Fernández and Navarro, Belén and Salcedo, Isabel and Abrisqueta, Pau and Español, Ignacio and Cornago, Javier and Martín Moro, Fernando and García, Lucía and Puente Pomposo, María},
}