@article{10902/37429,
year = {2025},
url = {https://hdl.handle.net/10902/37429},
abstract = {A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.},
publisher = {Nature Publishing Group},
publisher = {Nature Genetics, 2025, 57, 1598-1610},
title = {Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations},
author = {Nicolas, Aude and Sherva, Richard and Grenier-Boley, Bejamin and Dimi, Yoontae and Kikuchi, Masataka and Timsina, Jigyasha and Rojas, Itziar de and Dalmasso, María Carolina and Zhou, Xiaopu and Le Guen, Yann and Arboleda-Bustos, Carlos E. and Aparecida, María and Bicalho, Camargos and Guerchet, Maëlenn and Van der Lee, Sven and Goss, Mónica and Castillo, Atahualpa and Bellenguez, Céline and Rodríguez Rodríguez, Eloy Manuel},
}