@article{10902/36620,
year = {2025},
url = {https://hdl.handle.net/10902/36620},
abstract = {This study aims to analyze the factors associated with the lack of carbohydrate antigen 125 (CA-125) elevation in cases of acute heart failure (HF) decompensation. This retrospective study was conducted on 3167 consecutive patients admitted for acute HF in the cardiology department of a referral hospital (June 2019 to June 2024). Admissions from outpatient clinics (n: 1018) and transfers from other hospitals (n: 752) were excluded. The variables of interest included clinical, echocardiographic, therapeutic, and analytical factors. Low CA-125 levels were defined as values ? 50 U/mL. A total of 1397 patients were included, of whom 515 had normal CA-125 levels and 882 had elevated levels. Clinically, independent predictors of low CA-125 were sinus rhythm on electrocardiogram (OR: 1.42, 95% CI: 1.12-1.64; p: 0.003) and sleep apnea-hyponpnea syndrome (OR: 1.76, 95% CI: 1.15-2.70; p: 0.009). Echocardiographically, inferior vena cava collapse greater than 50% with inspiration was associated with low CA-125 (OR: 1.78, 95% CI: 1.19-2.69; p = 0.005), as well as with non-severe right ventricular dysfunction. (OR: 2.42; IC95%: 1.39-4.20; p: 0.002). Analytically, elevated NT-proBNP levels were associated with elevated CA-125 levels (OR: 0.99; IC95%: 0.99-0.99; p: 0.006). Survival was higher in the group with CA-125 ? 50 U/mL (p: 0.019). Conversely, as CA-125 values increased, mortality also rose. In conclusion, the absence of CA-125 elevation in patients admitted for acute HF is associated with sinus rhythm, sleep apnea-hyponpnea syndrome, low NT-proBNP levels, and inferior vena cava collapse greater than 50% with inspiration.},
publisher = {MDPI},
publisher = {Life, 2025, 15(3), 494},
title = {Predictive factors of non-elevation of carcinoembryonic antigen 125 in acute heart failure},
author = {López Vilella, Raquel and González Vílchez, Francisco Jesús and Guerrero Cervera, Borja and Donoso Trenado, Víctor and Saura Carretero, Zoser and Martínez Solé, Julia and Huélamo Montoro, Sara and Martínez Dolz, Luis and Almenar Bonet, Luis},
}