@article{10902/36489,
year = {2025},
url = {https://hdl.handle.net/10902/36489},
abstract = {Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.
Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model.
Results: A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death.
Conclusions: The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.},
organization = {Funding: ROCHE FARMA S.A. provided fnancial support for this study. Acknowledgments: The authors would like to thank the Spanish Foundation of Rheumatology for providing medical writing/editorial assistance during the preparation of the manuscript (FERBT2024).},
publisher = {BioMed Central},
publisher = {Arthritis Research & Therapy, 2025, 27(1), 4},
title = {Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry},
author = {Molina Collada, Juan and Domínguez Álvaro, Marta and Melero González, Rafael B. and De Miguel, Eugenio and Silva Díaz, Maite and Valero Jaimes, Jesús Alejandro and González, Ismael and Sánchez Martín, Julio and Narváez, Javier and Calvet, Joan and Casafont Solé, Ivette and Román Ivorra, Jose A and Labrada Arrabal, Selene and Vasques Rocha, Margarida and Iñiguez, Carlota L and Bustabad Reyes, María Sagrario and Campos Fernández, Cristina and Alcalde Villar, María and Mas, Antonio Juan and Blanco, Ricardo},
}