@article{10902/36485,
year = {2024},
url = {https://hdl.handle.net/10902/36485},
abstract = {Background/Objectives: Patients with rheumatic immune-mediated diseases (rheumatic-IMID) and latent tuberculosis (LTBI) are at an increased risk of developing active tuberculosis (TB); therefore, screening is recommended before starting biological treatment. The aims of this study were as follows: (i) to assess the prevalence of LTBI, (ii) to determine the importance of using a booster test in TST-negative patients, (iii) to compare the tuberculin skin test (TST) with the interferon-gamma release assay (IGRA), (iv) to perform a review of the prevalence of LTBI. Methods: A cross-sectional hospital study was performed, including patients diagnosed with rheumatic-IMID who underwent a TST and/or IGRA during the period 2016?2020. If the first TST was negative, a new TST (booster) was performed. Results: A total of 1117 patients were included. The overall prevalence of LTBI was estimated to be 31.7% (95% confidence interval, 29.74?33.66). The LTBI prevalence ranged from 38.5% for vasculitis to 14% for sarcoidosis. The booster test was positive in 22.9% of 817 patients with a negative or indeterminate IGRA. The IGRA was positive in 3.8% of 793 patients with a negative booster.The adjusted Cohen?s kappa coefficient between TST (+booster) and IGRA was 0.62. Conclusions: LTBI is frequent in patients with rheumatic-IMID. IGRA and TST (+booster) show a moderate, fair grade of agreement. Therefore, performing both tests before biological therapy should be highly recommended.},
publisher = {MDPI},
publisher = {Journal of Clinical Medicine, 2024, 13(24), 7546},
title = {Epidemiology of latent tuberculosis in rheumatic immune-mediated inflammatory diseases-Study of 1117 patients and descriptive literature review},
author = {Osorio Chávez, Joy Selene and Martínez López, David and Álvarez Reguera, Carmen and Portilla González, Virginia and Cifrián Martínez, José Manuel and Castañeda, Santos and Ferraz Amaro, Iván and Blanco Alonso, Ricardo},
}