@article{10902/36379,
year = {2025},
month = {3},
url = {https://hdl.handle.net/10902/36379},
abstract = {Water testing is becoming increasingly important due to dangerous phenomena such as Harmful Algal Blooms (HABs). Commonly, the content of a water sample is measured for the detection, monitoring and control of these events. Raman spectroscopy is a technique for the molecular characterization of materials in solid, liquid or gaseous form, which makes it an attractive method for analysing materials’ components. However, Raman scattering is a weak optical process and requires an accurate system for detection. In our work, we present, from design to fabrication, a microfluidic device on fused silica adapted to optimise the Raman spectrum of liquid samples when using a Raman probe. The device features a portable design for rapid on-site continuous flow measurements avoiding the use of large, costly and complex laboratory equipment. The main manufacturing technique used was ultrafast laser-assisted etching (ULAE). Finally, the effectiveness of the microfluidic device was demonstrated by comparing the Raman spectra of a known species of cyanobacteria with those obtained using other conventional substrates in laboratory analysis. The results demonstrate that the microfluidic device, under continuous flow conditions, exhibited a lower standard deviation of the Raman signal, reduced background noise and avoided signal variations caused by sample drying in static measurements.},
organization = {This work was supported by the R+D projects INNVAL23/10 and INNVAL24-28, and PREVAL23/05 funded by Instituto de Investigación Marqués de Valdecilla (IDIVAL); C.G.-G. acknowledges the University of Cantabria for the support provided through the Concepción Arenal PhD research grant; J.F.A. acknowledges RYC2022-035279-I, funded by MCIN/AEI/10.13039/501100011033 and FSE+; TED2021-130378BC21, funded by MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR; PID2022-137269OB-C22, funded by MCIN/AEI/10.13039/501100011033 and FEDER, UE; Plan Nacional de I+D+i and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, through CIBER-BBN (CB16/01/00430).},
publisher = {MDPI},
publisher = {Biosensors, 2025, 15(3), 172},
title = {Microfluidic device on fused silica for raman spectroscopy of liquid samples},
author = {Goméz Galdós, Celia and Pérez Asensio, Andrea and Fernández Manteca, María Gabriela and García García, Borja and Algorri Genaro, José Francisco and López Higuera, José Miguel and Rodríguez Cobo, Luis and Cobo García, Adolfo},
}