@conference{10902/36376,
year = {2024},
month = {6},
url = {https://hdl.handle.net/10902/36376},
abstract = {In this study, we applied Multispectral Mueller Matrix Imaging (MMI) at six distinct wavelengths in the visible range to analyze brain structures using lamb cerebral samples. The imaging of several brain sections revealed that white matter (WM) exhibits pronounced depolarization and retardance when contrasted with grey matter (GM), a phenomenon likely attributed to the elevated scattering and anisotropic nature of WM. More precisely, with an increase in wavelength, both depolarization and retardance also increase, suggesting additional penetration into deeper tissue layers. Employing various wavelengths enabled us to trace the shifts in the optical axis of retardance within the brain tissue, offering insights into the morphological changes in WM and GM below the cortical surface. The consistency observed in our results highlights the promise of Multispectral Wide-Field MMI as a non-intrusive, efficacious modality for probing brain architecture.},
organization = {Various institutions supported this article. This paper is independent research funded by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC), the Cancer Research UK (CRUK) Convergence Science Centre and the Wellcome Trust MedTechOne. Additional support came from the grant PREVAL 21/07 (FUSIOMUSCLE) funded by IDIVAL, as well as projects DTS22-00127 (hyPERfusioCAM), funded by Instituto de Salud Carlos III (ISCIII), TED2021-130378B-C21 (PALACE) funded by MCIN/AEI/10.13039/501100011033/European Union NextGenerationEU/PRTR; PID2022-137269OB-C22 (PERFORMANCE), and funded by MCIN/AEI/10.13039/501100011033/FEDER, UE. The authors also acknowledge the Zhejiang Provincial Natural Science Foundation of China under Grant No. LR23F050001. Mr. Giulio Anichini was financially supported by Brain Tumour Research (BTR), George Pickard's Research Fellowship, and Brain Tumour Research Campaign (BTRC). Mr. Kevin O'Neill was financially supported by Brain Tumour Research (BTR) and Brain Tumour Research Campaign (BTRC).},
publisher = {SPIE Society of Photo-Optical Instrumentation Engineers},
publisher = {Proceedings of SPIE,  2024, 13010, 130100G},
publisher = {Tissue Optics and Photonics III, Strasbourg, France, 2024},
title = {Multispectral Muller matrix imaging: a potential tool to visualize white matter tracts},
author = {Mieites Alonso, Verónica and Anichini, Giulio and Qi, Ji and O'Neill, Kevin and Conde Portilla, Olga María and Elson, Daniel},
}