@article{10902/36266, year = {2020}, url = {https://hdl.handle.net/10902/36266}, abstract = {Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding.}, organization = {Funding: This research was funded by the PN I+D+I 2008–2011 (Spain), ISCIII- Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF), RETICS Maternal and Child Health and Development Network, SAMID Network, Ref. RD16/0022/0015. Anna Parra-Llorca acknowledges Rio Hortega grant CM18/00165 from the Instituto de Investigación en Salud Carlos III (Ministry of Science, Universities and Innovation; Kingdom of Spain); Talía Sainz is funded by The Instituto de Salud Carlos III- Spanish Ministry of Science and Innovation cofounded by FEDER (EU). (Grant nº JR16/00021); Cristina Calvo is a member of the IdiPAZ Research Institute, Madrid. Spain. Translational Research Network for Pediatric Infectious Diseases (RITIP), Madrid, Spain. TEDDY Network Member (European Network of Excellence for Pediatric Clinical Research, Bari, Italy).}, publisher = {MDPI}, publisher = {Nutrients, 2020, 12(1), 133}, title = {The evolving microbiome from pregnancy to early infancy: a comprehensive review}, author = {Mesa, María Dolores and Loureiro, Begoña and Iglesia, Iris and Fernández González, Sergi and Llurba Olivé, Elisa and García Algar, Óscar and Solana, María José and Cabero Pérez, María Jesús and Sáinz, Talia and Martínez, Leopoldo and Escuder-Vieco, Diana and Parra-Llorca, Anna and Sánchez-Campillo, María and Rodríguez Martínez, Gerardo and Gómez Roig, Dolores and Pérez Gruz, Myriam and Andreu-Fernández, Vicente and Clotet, Jordi and Sailer, Sebastian and Iglesias-Platas, Isabel}, }