@article{10902/36189,
year = {2022},
url = {https://hdl.handle.net/10902/36189},
abstract = {Background: This study aims to evaluate the entire experience in heart-lung transplantation (HLTx) in a country of the European Union with 47 million inhabitants according to the etiologies that motivated the procedure.
Methods: A retrospective study on 1,751 consecutive transplants (HLTx: 78) was performed from 1990 to 2020 in two centers. Overall survival, adjusted for clinical profile and etiological subgroups, was compared. 7 subgroups were considered: 1) Cardiomyopathy with pulmonary hypertension (CM + PH). 2) Eisenmenger syndrome. 3) Congenital heart disease (CHD). 4) Idiopathic pulmonary arterial hypertension (IPAH). 5) Cystic fibrosis. 6) Chronic obstructive pulmonary disease (COPD)/Emphysema. 7) Diffuse interstitial lung disease (ILD).
Results: Early mortality was 44% and that of the rest of the follow-up was 31%. There were differences between HTLx and HTx in survival, also comparing groups with a similar clinical profile with propensity score (p= 0.04). Median survival was low in CM + PH (18 days), ILD (29 days) and CHD (114 days), intermediate in Eisenmenger syndrome (600 days), and longer in IPAH, COPD/Emphysema and cystic fibrosis.
Conclusion: HLTx has a high mortality. The etiological analysis is of the utmost interest to make the most of the organs and improve survival.},
publisher = {Avicenna Organ Transplant Institute},
publisher = {International Journal of Organ Transplantation Medicine, 2022, 13(2), 51-62},
title = {Current situation and prognostic evolution of combined heart-lung transplantation in a European Union country},
author = {López-Vilella, R. and Gómez Bueno, M. and González Vílchez, Francisco Jesús and Sole Jover, A. and Laporta Hernández, R. and Vicente Guillén, R. and González Román, A. I. and Sánchez-Lázaro, I. and Hernández Pérez, F. and Sales Badfa, G. and Córdoba Peláez, M. D. M. and Torregrosa Puerta, S. and Forteza Gil, A. and Martínez Dolz, L. and Segovia Cubero, J. and Almenar Bonet, L.},
}