@article{10902/35973,
year = {2024},
url = {https://hdl.handle.net/10902/35973},
abstract = {Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51-69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO2 < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients.},
organization = {Acknowledgements: This study was supported by Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI, RD16/0016/0001 [JR-B, BG-G], RD16/0016/0005 [NS], and RD16/0016/0009 [JP, EC, JSC]), co-financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligence Growth 2014-2020. EC, JSC and JR-B received grants from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Proyectos de Investigación sobre el SARS-CoV-2 y la enfermedad COVID-19 (COV20/00370, COV20/00580, COV20/01031). EC and JSC also were supported by the grant IM22/INF/13 from the CIBERINFEC, Instituto de Salud Carlos III, Spain. This study was also supported by CIBERINFEC - Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU (EC and JS-C [CB21/13/00006], BG-G and JR-B (CB21/13/00012). JSC is a researcher belonging to the program “Nicolás Monardes” (RC-0002–2022), Servicio Andaluz de Salud, Junta de Andalucía, Spain. The ORCHESTRA project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167.},
publisher = {Nature Publishing Group},
publisher = {Scientific Reports, 2024, 14(1), 30021},
title = {COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study},
author = {Infante Domínguez, Carmen and Salto Alejandre, Sonsoles and Álvarez Marín, Rocío and Sabé, Nuria and Ramos Martínez, Antonio and Moreno, Asunción and Ferreira de Moraes, Kamilla and Palacios Baena, Zaira R and Muñoz, Patricia and Fernández Ruiz, Mario and Blanes, Marino and Fariñas Álvarez, María del Carmen and Vidal, Elisa and Merino de Lucas, Esperanza and Halpern, Márcia and Hernández-Gallego, Román and Bassetti, Matteo and Mularoni, Alessandra and Gutiérrez-Dalmau, Alex and Rinaldi, Matteo},
}