@article{10902/35805,
year = {2024},
url = {https://hdl.handle.net/10902/35805},
abstract = {The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL).
Methods: Cross-sectional analysis of data from 805 survivors from the MCC study was conducted. HRQoL was assessed through a general and specific questionnaire, SF-12 and FCSI (Colorectal Symptom Index). Statistical analyses were performed with linear regression with adjustment for sociodemographic variables, stage at diagnosis and histological grade.
Results: Participants had survived a median of 7.9 years from diagnosis (IQR 7.1-8.5 years). Age at diagnosis, sex and area showed a clear association with HRQoL in both physical and mental dimensions of the SF-12 questionnaire. A direct association between CRC recurrence was also found in the PCS-12 and MCS-12 dimensions and radical surgery in the PCS-12. Regarding the scores in FCSI questionnaire, statistically significant differences were observed by sex, age and area, with older women being the most impaired (p < 0.001).
Conclusions: Age, sex and area was associated with lower scores of HRQoL among CRC survivors. Knowing the determinants related to HRQoL would allow us to lay the groundwork to develop strategies that help reduce morbidity and mortality, relapses and increase HRQoL.},
organization = {Funding: This study was partially funded by the “Acción Transversal del Cancer”, approved on the Spanish Ministry Council on the 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PS09/01286-León), by the Junta de Castilla y León (LE22A10-2), by Junta de Andalucía PI-0571(2010) and by the Instituto de Salud Carlos III (PI15/01032, PS09/2078, PI12/00265).},
publisher = {MDPI},
publisher = {Healthcare, 2024, 12(19), 1917},
title = {Health-related quality of life in long-term colorectal cancer survivors},
author = {Marcos Delgado, Alba and Martín Sánchez, Vicente and Molina Barceló, Ana and Alonso Molero, Jessica and Pérez Gómez, Beatriz and Pollán, Marina and Aragonés, Nuria and Ederra Sanza, María and Fernández Tardón, Guillermo and Binefa, Gemma and Moreno, Victor and Barrios Rodríguez, Rocío and Amiano, Pilar and Huerta, José María and Pastor Teso, Enrique and Alguacil, Juan and Castaño Vinyals, Gemma and Kogevinas, Manolis and Molina de la Torre, Antonio José},
}