@article{10902/35600,
year = {2024},
url = {https://hdl.handle.net/10902/35600},
abstract = {Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-alfa in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor's plasma levels of TNF-alfa were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-alfa plasma levels in donors are associated with a higher incidence of PGD.},
organization = {Funding: The author(s) declare(s) financial support was received for the research, authorship, publication of this article. The author(s) declare(s) that this work was performed with the financial support of Fundación Invest. Médica Mutua Madrileña Ref: AP167192017. Acknowledgments: Authors thank Leví Nuñez del Barrio, Anna Elena Gil Martinez, Ivette Castellnou Asens, Isshak Mrabet Deraoui, Elena Bechtold Javier, Beatriz Carrillo Cubero, Freddy Chilán Santana, Sonia Ramon-Cortes, Hermes Salvatore Dallo, Alba Gómez del Pulgar Martínez, Lucas Lozano Ramos, María Figueras Ravell, Christian Surós Álvarez, Sonia López Montero, from the Teaching Unit of the Vall d’Hebron Universitary Hospital–Autonomous University of Barcelona (Spain) for their contribution in the collection and processing of the blood samples.},
publisher = {Blackwell Publishing Ltd},
publisher = {Transplant International, 2024, 37, 12512},
title = {Systemic inflammation differences in brain-vs. circulatory-dead donors: impact on lung transplant recipients},
author = {Sandiumenge, Alberto and Bello, Irene and Coll-Torres, Elisabeth and Gómez-Brey, Aroa and Franco-Jarava, Clara and Miñambres García, Eduardo and Pérez-Redondo, Marina and Mosteiro, Fernando and Sánchez Moreno, Laura and Crowley, Silvana and Fieira, Eva and Suberviola, Borja and Mazo, Cristopher Alan and Agustí, Alvar and Pont, Teresa},
}